Multi-center, Open Label, Randomized Trial Comparing Single Versus Double Umbilical Cord Blood (UCB) Transplantation in Pediatric Patients With High Risk Leukemia and Myelodysplasia (BMT CTN #0501)
The trial, sponsored by the Medical College of Wisconsin, investigates the efficacy of single versus double umbilical cord blood transplantation in pediatric patients with high-risk leukemia and myelodysplasia. Given the increasing prevalence of hematologic malignancies in children and the potential for improved outcomes with double UCB transplants, this study could significantly impact treatment protocols and market dynamics in pediatric oncology. Successful results may enhance the competitive positioning of UCB transplantation as a standard of care, potentially influencing reimbursement policies and attracting interest from biopharma companies focused on hematological therapies.
Indication: Acute Myelogenous Leukemia
Modality: protein therapy
Target: Umbilical Cord Blood (UCB) Transplantation
Sponsor: Medical College of Wisconsin
Source URL: ClinicalTrials.gov
Source updated: Detailed source ingestion pending
Ingested: Jul 14, 2026
Model: trialsignal-ai-v1
Validation: validated
Matched by target_normalized: Umbilical Cord Blood (UCB) Transplantation
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Condition raw: Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia, Chronic Myelogenous Leukemia, Myelodysplastic Syndrome, Natural Killer Cell Lymphoblastic Leukemia/Lymphoma
Condition normalized: Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia, Chronic Myelogenous Leukemia, Myelodysplastic Syndrome, Natural Killer Cell Lymphoblastic Leukemia/Lymphoma
Modality raw: protein therapy
Modality normalized: protein therapy
Target raw: Umbilical Cord Blood (UCB) Transplantation
Target normalized: Umbilical Cord Blood (UCB) Transplantation