Comparison of Two Regimens of Artemether-lumefantrine for the Treatment of Uncomplicated Plasmodium Falciparum Malaria in Pregnant Women in the Democratic Republic of Congo
The trial compares two regimens of artemether-lumefantrine (ALN) for treating uncomplicated Plasmodium falciparum malaria in pregnant women, a demographic often excluded from clinical studies. Given the high morbidity and mortality associated with malaria in pregnancy, successful outcomes could enhance ALN's market position in regions with high malaria prevalence, particularly in sub-Saharan Africa. The findings may lead to revised dosing recommendations, potentially increasing the drug's usage and market share. The study's completion may also attract interest from public health organizations and NGOs focused on maternal and child health, further driving demand. However, the competitive landscape includes other antimalarial therapies, and the efficacy of ALN in this specific population will be critical for its commercial viability.
Indication: Malaria
Modality: small molecule
Target: Plasmodium falciparum malaria parasites
Sponsor: University of Oxford
Source URL: ClinicalTrials.gov
Source updated: Detailed source ingestion pending
Ingested: Jun 23, 2026
Model: trialsignal-ai-v1
Validation: validated
Matched by target_normalized: Plasmodium falciparum malaria parasites
View original source fields
Condition raw: Malaria
Condition normalized: Malaria
Modality raw: small molecule
Modality normalized: small molecule
Target raw: Plasmodium falciparum malaria parasites
Target normalized: Plasmodium falciparum malaria parasites