A Phase II Study of Cytokine Induced Memory-like NK Cell Adoptive Therapy After Haploidentical Donor Hematopoietic Cell Transplantation
This Phase II study, sponsored by Washington University School of Medicine, aims to improve leukemia-free survival rates in patients with refractory acute myeloid leukemia (AML) through the use of cytokine-induced memory-like NK cell adoptive therapy following haploidentical donor hematopoietic cell transplantation. The target market includes high-risk AML patients, a segment with significant unmet medical needs. If successful, this therapy could position itself favorably against existing treatments, particularly in a landscape where novel immunotherapies are gaining traction. The collaboration with entities such as the NIH and ImmunityBio, Inc. suggests a strong backing that may enhance credibility and facilitate future commercialization efforts. Diligence should focus on competitive landscape analysis, particularly regarding other NK cell therapies and their clinical outcomes.
Indication: Acute Myeloid Leukemia
Modality: small molecule
Target: Cytokine Induced Memory-like NK Cells (CIML NK cells)
Sponsor: Washington University School of Medicine
Source URL: ClinicalTrials.gov
Source updated: Detailed source ingestion pending
Ingested: Jul 09, 2026
Model: trialsignal-ai-v1
Validation: validated
Matched by target_normalized: Cytokine Induced Memory-like NK Cells (CIML NK cells)
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Condition raw: Acute Myeloid Leukemia
Condition normalized: Acute Myeloid Leukemia
Modality raw: small molecule
Modality normalized: small molecule
Target raw: Cytokine Induced Memory-like NK Cells (CIML NK cells)
Target normalized: Cytokine Induced Memory-like NK Cells (CIML NK cells)