TrialSignal
Clinical trial intelligence report
A Phase II Study of Cytokine Induced Memory-like NK Cell Adoptive Therapy After Haploidentical Donor Hematopoietic Cell Transplantation
Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.
Generated
Jul 28, 2026
Report code
NCT02782546-Jul 28, 2026
NCT ID
NCT02782546
Status
ACTIVE_NOT_RECRUITING
Phase
Phase 2
Sponsor
Washington University School of Medicine
Executive brief
Investment-Ready Snapshot
This Phase II study, sponsored by Washington University School of Medicine, aims to improve leukemia-free survival rates in patients with refractory acute myeloid leukemia (AML) through the use of cytokine-induced memory-like NK cell adoptive therapy following haploidentical donor hematopoietic cell transplantation. The target market includes high-risk AML patients, a segment with significant unmet medical needs. If successful, this therapy could position itself favorably against existing treatments, particularly in a landscape where novel immunotherapies are gaining traction. The collaboration with entities such as the NIH and ImmunityBio, Inc. suggests a strong backing that may enhance credibility and facilitate future commercialization efforts. Diligence should focus on competitive landscape analysis, particularly regarding other NK cell therapies and their clinical outcomes.
Source & freshness
Provenance
https://clinicaltrials.gov/study/NCT02782546
Indication
Acute Myeloid Leukemia
Modality
small molecule
Target
Cytokine Induced Memory-like NK Cells (CIML NK cells)
Intervention
Graft cell infusion, Tacrolimus, Mycophenolate mofetil, G-CSF, CIML NK cell infusion, ALT-803, Leukapheresis
Source record
Protocol Description
Detailed source ingestion pending.
Source record
Outcome Measures
Detailed source ingestion pending.
Source record
Eligibility
Detailed source ingestion pending.
AI analysis
Known Results And Readout Context
Detailed source ingestion pending.
IP intelligence
Patent And IP Landscape
Detailed source ingestion pending.
Source record
Contacts
Detailed source ingestion pending.