Open Label Positron Emission Tomography Study With [18F]AZD4694 and [11C]AZD2184, Candidate Radioligands for AB Amyloid, to Determine and Compare in Vivo Brain Uptake and Distribution in Healthy Volunteers and Patients With Alzheimer's Disease
The clinical trial conducted by AstraZeneca evaluates two candidate radioligands, [18F]AZD4694 and [11C]AZD2184, for their efficacy in imaging Aβ amyloid depositions in Alzheimer's Disease (AD) patients. Given the increasing prevalence of AD and the growing demand for effective diagnostic tools, successful outcomes from this study could position AstraZeneca favorably in the neuroimaging market. The trial's completion in 2009 suggests that AstraZeneca may have already progressed to subsequent phases or alternative studies, potentially enhancing their portfolio in Alzheimer's diagnostics. The competitive landscape includes other pharmaceutical companies and imaging technology firms focusing on similar radioligands, necessitating continuous monitoring of advancements in this space.
Indication: Alzheimer's Disease
Modality: radioligand therapy
Target: Aβ amyloid depositions in the human brain
Sponsor: AstraZeneca
Source URL: ClinicalTrials.gov
Source updated: Detailed source ingestion pending
Ingested: Jul 03, 2026
Model: trialsignal-ai-v1
Validation: validated
Matched by target_normalized: Aβ amyloid depositions in the human brain
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Condition raw: Alzheimer's Disease
Condition normalized: Alzheimer's Disease
Modality raw: radioligand therapy
Modality normalized: radioligand therapy
Target raw: Aβ amyloid depositions in the human brain
Target normalized: Aβ amyloid depositions in the human brain