This exploratory study, sponsored by the National Center of Neurology and Psychiatry in Japan, investigates the potential of the LIC Trainer device to improve respiratory function and prolong survival in ALS patients. The market for ALS therapies is expanding, with a growing focus on supportive care and rehabilitation strategies. If successful, the findings could position the LIC Trainer as a pivotal tool in respiratory rehabilitation for ALS, potentially leading to commercial opportunities in both Japan and globally. The absence of a control group necessitates careful interpretation of results, and further studies may be required to substantiate efficacy claims. Competitive implications include the need to monitor other emerging therapies targeting respiratory function in ALS, as well as alternative rehabilitation devices.