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Clinical trial intelligence report
Cognitive Reappraisal Training Targeting Emotion Circuits As a Therapeutic Intervention in Borderline Patients
Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.
Generated
Jul 28, 2026
Report code
NCT04967222-Jul 28, 2026
NCT ID
NCT04967222
Status
COMPLETED
Phase
Completed (R61 phase with plans for R33 phase)
Sponsor
Icahn School of Medicine at Mount Sinai
Executive brief
Investment-Ready Snapshot
The study, sponsored by the Icahn School of Medicine at Mount Sinai, explores a novel cognitive reappraisal training approach for treating Borderline Personality Disorder (BPD), a condition affecting 2% to 5.9% of the population with limited effective treatment options. Given the high prevalence and chronicity of BPD, successful outcomes could position this intervention as a valuable addition to the treatment landscape, potentially addressing unmet needs in a market characterized by a lack of approved pharmacological therapies. The results may enhance the competitive positioning of the sponsor and collaborators, including the National Institute of Mental Health (NIMH), in the field of psychiatric interventions. Diligence should focus on the scalability of the intervention and potential integration into existing treatment paradigms.
Source & freshness
Provenance
https://clinicaltrials.gov/study/NCT04967222
Indication
Borderline Personality Disorder
Modality
behavioral intervention
Target
Cognitive reappraisal training targeting emotion circuits, specifically focusing on the Picture Induced Negative Emotion Signature (PINES) network, including the amygdala and insula.
Intervention
Cognitive Reappraisal by Distancing, Control Downregulate Condition
Source record
Protocol Description
Detailed source ingestion pending.
Source record
Outcome Measures
Detailed source ingestion pending.
Source record
Eligibility
Detailed source ingestion pending.
AI analysis
Known Results And Readout Context
Detailed source ingestion pending.
IP intelligence
Patent And IP Landscape
Detailed source ingestion pending.
Source record
Contacts
Detailed source ingestion pending.