This pilot study, sponsored by the University Hospital of Toulouse, aims to evaluate the efficacy of the Mechanical In-Exsufflator (MIE) in improving respiratory function in patients with Amyotrophic Lateral Sclerosis (ALS). Given the lack of curative treatments for ALS, this study could position MIE as a supportive therapeutic device in respiratory management, potentially enhancing patient quality of life. The market for ALS management is growing, with increasing focus on supportive therapies. The results of this study may influence future reimbursement policies and market access strategies for MIE devices in Europe and beyond. Competitive implications include the need to monitor other respiratory support devices and therapies targeting ALS and similar neurodegenerative conditions.