The PeloPET study, sponsored by the Ohio State University Comprehensive Cancer Center, investigates the effects of free-base nicotine versus nicotine salt e-liquids on puffing behavior and nicotine absorption. Given the increasing prevalence of e-cigarette use and the ongoing regulatory scrutiny in the tobacco and nicotine market, the findings could provide critical insights for public health officials and regulators. This study may influence product formulation and marketing strategies for e-cigarette manufacturers, as well as inform potential future therapeutic applications targeting nicotine addiction. The competitive landscape includes major e-cigarette brands and emerging players focusing on product safety and efficacy.