The pilot study conducted by the University of Michigan explores the feasibility of using custom 3D printed masks for ALS patients who experience difficulties with traditional non-invasive ventilation (NIV) masks. Given the increasing prevalence of ALS and the critical need for effective NIV solutions, this innovation could address a significant gap in the market. The potential for improved patient compliance and quality of life may attract interest from medical device manufacturers and investors. However, the termination of the study due to COVID-19 restrictions may impact timelines and further development. Competitive analysis should focus on existing NIV mask solutions and emerging technologies in personalized medical devices.