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NCT05797259COMPLETEDanonymous

RANKL Antibody (Danosumab) for Acute Charcot Neuro-osteoarthropathy Remission in Chronic Kidney Disease

Sponsor

Source record

Post Graduate Institute of Medical Education and Research, Chandigarh

Phase

Source record

PHASE4

Modality

AI-normalized

monoclonal antibody

Target

AI-normalized

Danosumab, Normal Saline

Indication / condition

AI-normalized

Charcot Joint of Foot

Intervention

Source record

Danosumab, Normal Saline

Source & freshness

Source record

NCT ID

NCT05797259

Original source

ClinicalTrials.gov

Source last updated

Aug 30, 2023

Ingested at

Jun 19, 2026

Internal sync

Jun 19, 2026

Model version

trialsignal-ai-v1

Normalized confidence

96%

Validation status

validated

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NCT ID

NCT05797259

Title

RANKL Antibody (Danosumab) for Acute Charcot Neuro-osteoarthropathy Remission in Chronic Kidney Disease

Sponsor

Post Graduate Institute of Medical Education and Research, Chandigarh

Status

COMPLETED

Phase

PHASE4

Condition raw

Charcot Joint of Foot

Condition normalized

Charcot Joint of Foot

Modality raw

monoclonal antibody

Modality normalized

monoclonal antibody

Target raw

Danosumab, Normal Saline

Target normalized

Danosumab, Normal Saline

Interventions

Danosumab, Normal Saline

Public preview

Source record

This study's goal was to determine how denosumab 60 mg, combined with total contact casting and restricted weightbearing status, would affect the treatment of acute CN with CKD.

METHODS Participants in the research were those who visited the outpatient foot clinic at PGIMER, CHD in India. During the study period, 446 persons with CN were identified, 102 of whom met the criteria for the first screening, and 78 of whom were ultimately enrolled in the study.

Aim: To assess the clinico-radiological remission of Acute Charcot-neuroarthropathy in patients of CKD.

AI-generated analysis supports research triage only. Verify source records, publications, sponsor disclosures and IP databases before making diligence decisions. Model: trialsignal-ai-v1.

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