TrialSignal
Clinical trial intelligence report
The Suppression of Toll Like Receptors by Insulin
Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.
Generated
Jun 19, 2026
NCT ID
NCT01151605
Status
COMPLETED
Phase
Completed (not classified in traditional phases)
Sponsor
University at Buffalo
Executive brief
Investment-Ready Snapshot
The study investigates the anti-inflammatory effects of insulin on Toll Like Receptors (TLRs), which are implicated in atherosclerosis and cardiovascular diseases. Given the rising prevalence of obesity and type 2 diabetes, this research could provide insights into novel therapeutic approaches for managing inflammation-related complications in these populations. The findings may enhance the value proposition of insulin therapies, particularly in the context of cardiovascular health, potentially leading to expanded indications and market opportunities. The collaboration with the American Diabetes Association may also enhance credibility and visibility within the diabetes care community. However, the competitive landscape includes existing anti-inflammatory agents and novel therapies targeting similar pathways, necessitating a thorough competitive analysis.
Source & freshness
Provenance
https://clinicaltrials.gov/study/NCT01151605
Indication
Insulin Resistance
Modality
small molecule
Target
Toll Like Receptors (TLRs) - specifically TLR2, TLR4, TLR7, and TLR9
Intervention
insulin infusion, Dextrose infusion, Saline Infusion
Source record
Protocol Description
Detailed source ingestion pending.
Source record
Outcome Measures
Detailed source ingestion pending.
Source record
Eligibility
Detailed source ingestion pending.
AI analysis
Known Results And Readout Context
Detailed source ingestion pending.
IP intelligence
Patent And IP Landscape
Detailed source ingestion pending.
Source record
Contacts
Detailed source ingestion pending.