Report workspace

Add to folder
NCT01151605COMPLETEDanonymous

The Suppression of Toll Like Receptors by Insulin

Sponsor

Source record

University at Buffalo

Phase

Source record

Completed (not classified in traditional phases)

Modality

AI-normalized

small molecule

Target

AI-normalized

Toll Like Receptors (TLRs) - specifically TLR2, TLR4, TLR7, and TLR9

Indication / condition

AI-normalized

Insulin Resistance

Intervention

Source record

insulin infusion, Dextrose infusion, Saline Infusion

Source & freshness

Source record

NCT ID

NCT01151605

Original source

ClinicalTrials.gov

Source last updated

Jan 05, 2024

Ingested at

Jun 19, 2026

Internal sync

Jun 19, 2026

Model version

trialsignal-ai-v1

Normalized confidence

96%

Validation status

validated

Open original registry record
View original source fields

NCT ID

NCT01151605

Title

The Suppression of Toll Like Receptors by Insulin

Sponsor

University at Buffalo

Status

COMPLETED

Phase

Completed (not classified in traditional phases)

Condition raw

Insulin Resistance

Condition normalized

Insulin Resistance

Modality raw

small molecule

Modality normalized

small molecule

Target raw

Toll Like Receptors (TLRs) - specifically TLR2, TLR4, TLR7, and TLR9

Target normalized

Toll Like Receptors (TLRs) - specifically TLR2, TLR4, TLR7, and TLR9

Interventions

insulin infusion, Dextrose infusion, Saline Infusion

Public preview

Source record

The study investigates the anti-inflammatory effects of insulin on Toll Like Receptors (TLRs), which are implicated in atherosclerosis and cardiovascular diseases. Given the rising prevalence of obesity and type 2 diabetes, this research could provide insights into novel therapeutic approaches for managing inflammation-related complications in these populations. The findings may enhance the value proposition of insulin therapies, particularly in the context of cardiovascular health, potentially leading to expanded indications and market opportunities. The collaboration with the American Diabetes Association may also enhance credibility and visibility within the diabetes care community. However, the competitive landscape includes existing anti-inflammatory agents and novel therapies targeting similar pathways, necessitating a thorough competitive analysis.

AI-generated analysis supports research triage only. Verify source records, publications, sponsor disclosures and IP databases before making diligence decisions. Model: trialsignal-ai-v1.

Report access

Create an account to unlock this report

Choose the access model that matches the job: one urgent report, reusable credits for project work, or unlimited monthly access with AI and folders.

Early access offer

Subscribe with code FOUNDERS5 for a 5-day premium trial.

Full protocol, outcomes, eligibility, contacts and results sections
Patent/IP landscape with verified records when available
Board-ready PDF export with source provenance
Save to folders and synthesize multiple assets in premium workspace
Create account

Create a free account first, then unlock a single report, buy credits or subscribe.