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NCT02370745COMPLETEDanonymous

Characterizing the Incretin Effect of Amino Acids (AA) and Defining the Effect of GLP-1 on Muscle Microvascular Blood Flow and Muscle Protein and Glucose Metabolism in Older Age.

Sponsor

Source record

University of Nottingham

Phase

Source record

Completed

Modality

AI-normalized

small molecule

Target

AI-normalized

Incretin effect modulation via amino acids and GLP-1 on muscle microvascular blood flow and metabolism.

Indication / condition

AI-normalized

Sarcopenia

Intervention

Source record

GLP-1, Insulin Actrapid, Oral amino acids, GIP, Intravenous amino acids

Source & freshness

Source record

NCT ID

NCT02370745

Original source

ClinicalTrials.gov

Source last updated

May 02, 2018

Ingested at

Jun 19, 2026

Internal sync

Jun 19, 2026

Model version

trialsignal-ai-v1

Normalized confidence

96%

Validation status

validated

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NCT ID

NCT02370745

Title

Characterizing the Incretin Effect of Amino Acids (AA) and Defining the Effect of GLP-1 on Muscle Microvascular Blood Flow and Muscle Protein and Glucose Metabolism in Older Age.

Sponsor

University of Nottingham

Status

COMPLETED

Phase

Completed

Condition raw

Sarcopenia

Condition normalized

Sarcopenia

Modality raw

small molecule

Modality normalized

small molecule

Target raw

Incretin effect modulation via amino acids and GLP-1 on muscle microvascular blood flow and metabolism.

Target normalized

Incretin effect modulation via amino acids and GLP-1 on muscle microvascular blood flow and metabolism.

Interventions

GLP-1, Insulin Actrapid, Oral amino acids, GIP, Intravenous amino acids

Public preview

Source record

This study, sponsored by the University of Nottingham, investigates the effects of amino acids and GLP-1 on muscle metabolism and microvascular blood flow in younger and older adults. The findings could have significant implications for the treatment of sarcopenia and metabolic disorders, particularly in the aging population. Given the increasing prevalence of age-related muscle loss and metabolic diseases, there is a growing market for therapies targeting muscle health and metabolic regulation. The results may enhance the understanding of GLP-1's role beyond glucose regulation, potentially influencing the development of new therapeutic strategies or dietary supplements. Competitive implications include positioning against existing GLP-1 receptor agonists and other metabolic modulators, necessitating a thorough analysis of the data to assess differentiation and potential market entry strategies.

AI-generated analysis supports research triage only. Verify source records, publications, sponsor disclosures and IP databases before making diligence decisions. Model: trialsignal-ai-v1.

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