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Study 200977: Albiglutide + Insulin Glargine Versus Insulin Lispro + Insulin Glargine in the Treatment of Subjects With Type 2 Diabetes Mellitus: The Switch Study

Sponsor

Source record

GlaxoSmithKline

Phase

Source record

Phase 3b

Modality

AI-normalized

small molecule

Target

AI-normalized

Glucagon-like peptide-1 receptor (GLP-1R)

Indication / condition

AI-normalized

Diabetes Mellitus, Type 2

Intervention

Source record

Albiglutide, Insulin Glargine and Insulin Lispro

Source & freshness

Source record

NCT ID

NCT02229227

Original source

ClinicalTrials.gov

Source last updated

Nov 27, 2020

Ingested at

Jun 19, 2026

Internal sync

Jun 19, 2026

Model version

trialsignal-ai-v1

Normalized confidence

96%

Validation status

validated

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NCT ID

NCT02229227

Title

Study 200977: Albiglutide + Insulin Glargine Versus Insulin Lispro + Insulin Glargine in the Treatment of Subjects With Type 2 Diabetes Mellitus: The Switch Study

Sponsor

GlaxoSmithKline

Status

COMPLETED

Phase

Phase 3b

Condition raw

Diabetes Mellitus, Type 2

Condition normalized

Diabetes Mellitus, Type 2

Modality raw

small molecule

Modality normalized

small molecule

Target raw

Glucagon-like peptide-1 receptor (GLP-1R)

Target normalized

Glucagon-like peptide-1 receptor (GLP-1R)

Interventions

Albiglutide, Insulin Glargine and Insulin Lispro

Public preview

Source record

The Switch Study, sponsored by GlaxoSmithKline, evaluates the efficacy and safety of albiglutide in combination with insulin glargine compared to a traditional basal-bolus insulin regimen in patients with Type 2 Diabetes Mellitus (T2DM) who are not achieving adequate glycemic control. With approximately 794 participants, the study aims to address the growing need for effective diabetes management solutions, particularly in patients struggling with complex insulin regimens. The results may position albiglutide as a viable alternative to conventional insulin therapies, potentially enhancing GSK's portfolio in the diabetes market, which is characterized by intense competition from established players like Novo Nordisk and Sanofi. The findings could influence market dynamics, particularly if albiglutide demonstrates superior efficacy or safety profiles, leading to increased adoption in clinical practice.

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