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NCT01256073COMPLETEDanonymous

An Open-label, Safety and Tolerability Extension Trial Assessing Repeated Dosing of Anti-KIR (1-7F9) Human Monoclonal Antibody in Patients With Acute Myeloid Leukaemia

Sponsor

Source record

Innate Pharma

Phase

Source record

Phase 1

Modality

AI-normalized

monoclonal antibody

Target

AI-normalized

Killer Immunoglobulin-like Receptor (KIR) on Natural Killer (NK) cells

Indication / condition

AI-normalized

Acute Myeloid Leukemia

Intervention

Source record

IPH2101

Source & freshness

Source record

NCT ID

NCT01256073

Original source

ClinicalTrials.gov

Source last updated

Feb 28, 2014

Ingested at

Jun 18, 2026

Internal sync

Jun 18, 2026

Model version

trialsignal-ai-v1

Normalized confidence

96%

Validation status

validated

Open original registry record
View original source fields

NCT ID

NCT01256073

Title

An Open-label, Safety and Tolerability Extension Trial Assessing Repeated Dosing of Anti-KIR (1-7F9) Human Monoclonal Antibody in Patients With Acute Myeloid Leukaemia

Sponsor

Innate Pharma

Status

COMPLETED

Phase

Phase 1

Condition raw

Acute Myeloid Leukemia

Condition normalized

Acute Myeloid Leukemia

Modality raw

monoclonal antibody

Modality normalized

monoclonal antibody

Target raw

Killer Immunoglobulin-like Receptor (KIR) on Natural Killer (NK) cells

Target normalized

Killer Immunoglobulin-like Receptor (KIR) on Natural Killer (NK) cells

Interventions

IPH2101

Public preview

Source record

Innate Pharma's IPH2101 (Anti-KIR (1-7F9)) is positioned within a niche market targeting elderly patients with Acute Myeloid Leukemia (AML) who are in complete remission but are ineligible for allogeneic stem-cell transplantation. The focus on safety and tolerability in this population addresses a significant unmet need, as treatment options are limited for this demographic. The competitive landscape includes other immunotherapeutic approaches for AML, but IPH2101's unique mechanism targeting KIR may provide a differentiated profile. The successful completion of this trial could enhance Innate Pharma's portfolio and attract potential partnerships or acquisition interest, particularly from larger oncology-focused biopharma companies seeking to expand their hematological malignancy offerings.

AI-generated analysis supports research triage only. Verify source records, publications, sponsor disclosures and IP databases before making diligence decisions. Model: trialsignal-ai-v1.

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