TrialSignal
Clinical trial intelligence report
An Open-label Randomized Controlled Phase II Study of AS1411 Combined With Cytarabine in the Treatment of Patients With Primary Refractory or Relapsed Acute Myeloid Leukemia
Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.
Generated
Jun 18, 2026
NCT ID
NCT01034410
Status
TERMINATED
Phase
Phase 2
Sponsor
Antisoma Research
Executive brief
Investment-Ready Snapshot
AS1411, in combination with Cytarabine, targets patients with primary refractory or relapsed Acute Myeloid Leukemia (AML), a market characterized by high unmet medical need and limited treatment options. The study's termination suggests potential challenges in efficacy or safety, which may impact Antisoma Research's strategic positioning and investor confidence. The competitive landscape includes established therapies like Cytarabine and emerging agents, necessitating a thorough evaluation of AS1411's differentiation and market viability. Diligence should focus on the implications of trial outcomes on future development pathways and potential partnerships.
Source & freshness
Provenance
https://clinicaltrials.gov/study/NCT01034410
Indication
Acute Myeloid Leukemia
Modality
small molecule
Target
Nucleolin (as AS1411 is an aptamer targeting nucleolin)
Intervention
AS1411, Cytarabine
Source record
Protocol Description
Detailed source ingestion pending.
Source record
Outcome Measures
Detailed source ingestion pending.
Source record
Eligibility
Detailed source ingestion pending.
AI analysis
Known Results And Readout Context
Detailed source ingestion pending.
IP intelligence
Patent And IP Landscape
Detailed source ingestion pending.
Source record
Contacts
Detailed source ingestion pending.