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NCT01034410TERMINATEDanonymous

An Open-label Randomized Controlled Phase II Study of AS1411 Combined With Cytarabine in the Treatment of Patients With Primary Refractory or Relapsed Acute Myeloid Leukemia

Sponsor

Source record

Antisoma Research

Phase

Source record

Phase 2

Modality

AI-normalized

small molecule

Target

AI-normalized

Nucleolin (as AS1411 is an aptamer targeting nucleolin)

Indication / condition

AI-normalized

Acute Myeloid Leukemia

Intervention

Source record

AS1411, Cytarabine

Source & freshness

Source record

NCT ID

NCT01034410

Original source

ClinicalTrials.gov

Source last updated

Feb 02, 2011

Ingested at

Jun 18, 2026

Internal sync

Jun 18, 2026

Model version

trialsignal-ai-v1

Normalized confidence

96%

Validation status

validated

Open original registry record
View original source fields

NCT ID

NCT01034410

Title

An Open-label Randomized Controlled Phase II Study of AS1411 Combined With Cytarabine in the Treatment of Patients With Primary Refractory or Relapsed Acute Myeloid Leukemia

Sponsor

Antisoma Research

Status

TERMINATED

Phase

Phase 2

Condition raw

Acute Myeloid Leukemia

Condition normalized

Acute Myeloid Leukemia

Modality raw

small molecule

Modality normalized

small molecule

Target raw

Nucleolin (as AS1411 is an aptamer targeting nucleolin)

Target normalized

Nucleolin (as AS1411 is an aptamer targeting nucleolin)

Interventions

AS1411, Cytarabine

Public preview

Source record

AS1411, in combination with Cytarabine, targets patients with primary refractory or relapsed Acute Myeloid Leukemia (AML), a market characterized by high unmet medical need and limited treatment options. The study's termination suggests potential challenges in efficacy or safety, which may impact Antisoma Research's strategic positioning and investor confidence. The competitive landscape includes established therapies like Cytarabine and emerging agents, necessitating a thorough evaluation of AS1411's differentiation and market viability. Diligence should focus on the implications of trial outcomes on future development pathways and potential partnerships.

AI-generated analysis supports research triage only. Verify source records, publications, sponsor disclosures and IP databases before making diligence decisions. Model: trialsignal-ai-v1.

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