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NCT00707759COMPLETEDanonymous

Multicenter, Open-Label, Randomized Study on Steroid-Free Immunosuppression, in Comparison With Daily Steroid Therapy, in Pediatric Renal Transplant : Impact on Growth, Bone Metabolism and Acute Rejection

Sponsor

Source record

Fondo Nacional de Desarrollo Científico y Tecnológico, Chile

Phase

Source record

Phase 3

Modality

AI-normalized

small molecule

Target

AI-normalized

IL-2 receptor signaling pathway, Tacrolimus (TAC), Mycophenolate Mofetil (MMF), IL-17, FOXP3

Indication / condition

AI-normalized

Kidney Diseases

Intervention

Source record

Tacrolimus (TAC)+ Mycophenolate Mofetil (MMF) + Withdrawal Prednisone, Tacrolimus (TAC)+ Mycophenolate Mofetil (MMF) + prednisolone

Source & freshness

Source record

NCT ID

NCT00707759

Original source

ClinicalTrials.gov

Source last updated

Nov 10, 2015

Ingested at

Jun 18, 2026

Internal sync

Jun 18, 2026

Model version

trialsignal-ai-v1

Normalized confidence

96%

Validation status

validated

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NCT ID

NCT00707759

Title

Multicenter, Open-Label, Randomized Study on Steroid-Free Immunosuppression, in Comparison With Daily Steroid Therapy, in Pediatric Renal Transplant : Impact on Growth, Bone Metabolism and Acute Rejection

Sponsor

Fondo Nacional de Desarrollo Científico y Tecnológico, Chile

Status

COMPLETED

Phase

Phase 3

Condition raw

Kidney Diseases

Condition normalized

Kidney Diseases

Modality raw

small molecule

Modality normalized

small molecule

Target raw

IL-2 receptor signaling pathway, Tacrolimus (TAC), Mycophenolate Mofetil (MMF), IL-17, FOXP3

Target normalized

IL-2 receptor signaling pathway, Tacrolimus (TAC), Mycophenolate Mofetil (MMF), IL-17, FOXP3

Interventions

Tacrolimus (TAC)+ Mycophenolate Mofetil (MMF) + Withdrawal Prednisone, Tacrolimus (TAC)+ Mycophenolate Mofetil (MMF) + prednisolone

Public preview

Source record

This clinical trial, sponsored by the Fondo Nacional de Desarrollo Científico y Tecnológico in Chile, investigates a steroid-free immunosuppression regimen in pediatric renal transplant patients. The potential success of this study could position the sponsor favorably in the pediatric transplant market, which is increasingly focused on minimizing steroid use due to associated growth and metabolic side effects. If the results demonstrate improved growth and bone metabolism without increased rejection rates, this could lead to a competitive advantage over existing steroid-based therapies. Additionally, the findings may attract interest from pharmaceutical companies looking to develop or enhance immunosuppressive therapies for pediatric patients, indicating potential partnership or acquisition opportunities.

AI-generated analysis supports research triage only. Verify source records, publications, sponsor disclosures and IP databases before making diligence decisions. Model: trialsignal-ai-v1.

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