TrialSignal
Clinical trial intelligence report
The Role of Plasminogen Activator Inhibitor-1 (PAI-1), Tissue Plasminogen Activator (tPA), Tissue Factor Pathway Inhibitor (TFPI), and Endometrial Endothelial Cells in Uterine Hemostasis in Humans
Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.
Generated
Jun 18, 2026
NCT ID
NCT05862805
Status
RECRUITING
Phase
Phase 1/2
Sponsor
Oregon Health and Science University
Executive brief
Investment-Ready Snapshot
The clinical trial, sponsored by Oregon Health and Science University, aims to elucidate the roles of specific blood clotting factors and endothelial cells in menstrual bleeding, particularly focusing on heavy menstrual bleeding (HMB). The study is currently recruiting participants aged 18-45, which represents a significant demographic affected by HMB. The findings could lead to novel therapeutic targets for managing HMB, a condition that affects a substantial portion of menstruating individuals and is often inadequately addressed by current treatments. The potential market for HMB therapies is considerable, given the prevalence of the condition and the dissatisfaction with existing options. Competitive analysis indicates a gap in targeted therapies, suggesting a favorable position for any resultant innovations from this study. Diligence should focus on the regulatory landscape and potential partnerships for commercialization.
Source & freshness
Provenance
https://clinicaltrials.gov/study/NCT05862805
Indication
Menstrual Bleeding, Heavy
Modality
RNA therapy
Target
Plasminogen Activator Inhibitor-1 (PAI-1), Tissue Plasminogen Activator (tPA), Tissue Factor Pathway Inhibitor (TFPI), and Human Endometrial Endothelial Cells (HEECs)
Intervention
Sample Collection and Endometrial Biopsy
Source record
Protocol Description
Detailed source ingestion pending.
Source record
Outcome Measures
Detailed source ingestion pending.
Source record
Eligibility
Detailed source ingestion pending.
AI analysis
Known Results And Readout Context
Detailed source ingestion pending.
IP intelligence
Patent And IP Landscape
Detailed source ingestion pending.
Source record
Contacts
Detailed source ingestion pending.