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NCT05862805RECRUITINGanonymous

The Role of Plasminogen Activator Inhibitor-1 (PAI-1), Tissue Plasminogen Activator (tPA), Tissue Factor Pathway Inhibitor (TFPI), and Endometrial Endothelial Cells in Uterine Hemostasis in Humans

Sponsor

Source record

Oregon Health and Science University

Phase

Source record

Phase 1/2

Modality

AI-normalized

RNA therapy

Target

AI-normalized

Plasminogen Activator Inhibitor-1 (PAI-1), Tissue Plasminogen Activator (tPA), Tissue Factor Pathway Inhibitor (TFPI), and Human Endometrial Endothelial Cells (HEECs)

Indication / condition

AI-normalized

Menstrual Bleeding, Heavy

Intervention

Source record

Sample Collection and Endometrial Biopsy

Source & freshness

Source record

NCT ID

NCT05862805

Original source

ClinicalTrials.gov

Source last updated

Aug 19, 2024

Ingested at

Jun 18, 2026

Internal sync

Jun 18, 2026

Model version

trialsignal-ai-v1

Normalized confidence

96%

Validation status

validated

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NCT ID

NCT05862805

Title

The Role of Plasminogen Activator Inhibitor-1 (PAI-1), Tissue Plasminogen Activator (tPA), Tissue Factor Pathway Inhibitor (TFPI), and Endometrial Endothelial Cells in Uterine Hemostasis in Humans

Sponsor

Oregon Health and Science University

Status

RECRUITING

Phase

Phase 1/2

Condition raw

Menstrual Bleeding, Heavy

Condition normalized

Menstrual Bleeding, Heavy

Modality raw

RNA therapy

Modality normalized

RNA therapy

Target raw

Plasminogen Activator Inhibitor-1 (PAI-1), Tissue Plasminogen Activator (tPA), Tissue Factor Pathway Inhibitor (TFPI), and Human Endometrial Endothelial Cells (HEECs)

Target normalized

Plasminogen Activator Inhibitor-1 (PAI-1), Tissue Plasminogen Activator (tPA), Tissue Factor Pathway Inhibitor (TFPI), and Human Endometrial Endothelial Cells (HEECs)

Interventions

Sample Collection and Endometrial Biopsy

Public preview

Source record

The clinical trial, sponsored by Oregon Health and Science University, aims to elucidate the roles of specific blood clotting factors and endothelial cells in menstrual bleeding, particularly focusing on heavy menstrual bleeding (HMB). The study is currently recruiting participants aged 18-45, which represents a significant demographic affected by HMB. The findings could lead to novel therapeutic targets for managing HMB, a condition that affects a substantial portion of menstruating individuals and is often inadequately addressed by current treatments. The potential market for HMB therapies is considerable, given the prevalence of the condition and the dissatisfaction with existing options. Competitive analysis indicates a gap in targeted therapies, suggesting a favorable position for any resultant innovations from this study. Diligence should focus on the regulatory landscape and potential partnerships for commercialization.

AI-generated analysis supports research triage only. Verify source records, publications, sponsor disclosures and IP databases before making diligence decisions. Model: trialsignal-ai-v1.

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