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NCT06742593NOT_YET_RECRUITINGanonymous

A Single-arm, Dose-escalating Phase I Clinical Trial to Evaluate the Tolerability, Safety, Pharmacokinetic , and Efficacy of MT027 in Patients with Brain, Meninges, and Spinal Cord Metastatic Solid Tumors

Sponsor

Source record

Suzhou Maximum Bio-tech Co., Ltd.

Phase

Source record

Phase 1

Modality

AI-normalized

cell therapy

Target

AI-normalized

B7-H3 (CD276), a co-inhibitory molecule involved in immune regulation, targeted by chimeric antigen receptor (CAR) T cells.

Indication / condition

AI-normalized

Brain (Nervous System) Cancers

Intervention

Source record

MT027 cells suspension

Source & freshness

Source record

NCT ID

NCT06742593

Original source

ClinicalTrials.gov

Source last updated

Dec 19, 2024

Ingested at

Jun 18, 2026

Internal sync

Jun 18, 2026

Model version

trialsignal-ai-v1

Normalized confidence

96%

Validation status

validated

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NCT ID

NCT06742593

Title

A Single-arm, Dose-escalating Phase I Clinical Trial to Evaluate the Tolerability, Safety, Pharmacokinetic , and Efficacy of MT027 in Patients with Brain, Meninges, and Spinal Cord Metastatic Solid Tumors

Sponsor

Suzhou Maximum Bio-tech Co., Ltd.

Status

NOT_YET_RECRUITING

Phase

Phase 1

Condition raw

Brain (Nervous System) Cancers, Brain and Central Nervous System Tumors, Brain Tumors

Condition normalized

Brain (Nervous System) Cancers, Brain and Central Nervous System Tumors, Brain Tumors

Modality raw

cell therapy

Modality normalized

cell therapy

Target raw

B7-H3 (CD276), a co-inhibitory molecule involved in immune regulation, targeted by chimeric antigen receptor (CAR) T cells.

Target normalized

B7-H3 (CD276), a co-inhibitory molecule involved in immune regulation, targeted by chimeric antigen receptor (CAR) T cells.

Interventions

MT027 cells suspension

Public preview

Source record

MT027, developed by Suzhou Maximum Bio-tech Co., Ltd., represents a next-generation allogeneic CAR-T therapy targeting B7-H3, specifically designed for patients with brain, meninges, and spinal cord metastatic solid tumors. The product addresses significant unmet medical needs by providing a ready-to-use treatment option that circumvents the lengthy production times and compatibility issues associated with autologous CAR-T therapies. The anticipated lower cost of MT027 may enhance patient access and reduce the economic burden on healthcare systems. The competitive landscape includes other CAR-T therapies, but MT027's unique allogeneic approach may position it favorably in the market, particularly for patients unable to receive traditional CAR-T therapies. The trial's outcomes will be critical for establishing its safety and efficacy profile, which will influence future market positioning and potential partnerships.

AI-generated analysis supports research triage only. Verify source records, publications, sponsor disclosures and IP databases before making diligence decisions. Model: trialsignal-ai-v1.

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