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A Single-arm, Dose-escalating Phase I Clinical Trial to Evaluate the Tolerability, Safety, Pharmacokinetic , and Efficacy of MT027 in Patients with Brain, Meninges, and Spinal Cord Metastatic Solid Tumors
Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.
Generated
Jun 18, 2026
NCT ID
NCT06742593
Status
NOT_YET_RECRUITING
Phase
Phase 1
Sponsor
Suzhou Maximum Bio-tech Co., Ltd.
Executive brief
Investment-Ready Snapshot
MT027, developed by Suzhou Maximum Bio-tech Co., Ltd., represents a next-generation allogeneic CAR-T therapy targeting B7-H3, specifically designed for patients with brain, meninges, and spinal cord metastatic solid tumors. The product addresses significant unmet medical needs by providing a ready-to-use treatment option that circumvents the lengthy production times and compatibility issues associated with autologous CAR-T therapies. The anticipated lower cost of MT027 may enhance patient access and reduce the economic burden on healthcare systems. The competitive landscape includes other CAR-T therapies, but MT027's unique allogeneic approach may position it favorably in the market, particularly for patients unable to receive traditional CAR-T therapies. The trial's outcomes will be critical for establishing its safety and efficacy profile, which will influence future market positioning and potential partnerships.
Source & freshness
Provenance
https://clinicaltrials.gov/study/NCT06742593
Indication
Brain (Nervous System) Cancers
Modality
cell therapy
Target
B7-H3 (CD276), a co-inhibitory molecule involved in immune regulation, targeted by chimeric antigen receptor (CAR) T cells.
Intervention
MT027 cells suspension
Source record
Protocol Description
Detailed source ingestion pending.
Source record
Outcome Measures
Detailed source ingestion pending.
Source record
Eligibility
Detailed source ingestion pending.
AI analysis
Known Results And Readout Context
Detailed source ingestion pending.
IP intelligence
Patent And IP Landscape
Detailed source ingestion pending.
Source record
Contacts
Detailed source ingestion pending.