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NCT06379451UNKNOWNanonymous

An Exploratory Clinical Study of the Safety and Efficacy of NKG2D Chimeric Antigen Receptor NK Cell Injections for the Treatment of Efractory Recurrent Multiple Myeloma

Sponsor

Source record

Changzhou No.2 People's Hospital

Phase

Source record

Early Phase 1

Modality

AI-normalized

small molecule

Target

AI-normalized

NKG2D receptor on NK cells, targeting NKG2D ligands (NKG2DL) expressed on tumor cells.

Indication / condition

AI-normalized

Multiple Myeloma

Intervention

Source record

NKG2D Chimeric Antigen Receptor NK Cell Injection

Source & freshness

Source record

NCT ID

NCT06379451

Original source

ClinicalTrials.gov

Source last updated

Apr 23, 2024

Ingested at

Jun 18, 2026

Internal sync

Jun 18, 2026

Model version

trialsignal-ai-v1

Normalized confidence

96%

Validation status

validated

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NCT ID

NCT06379451

Title

An Exploratory Clinical Study of the Safety and Efficacy of NKG2D Chimeric Antigen Receptor NK Cell Injections for the Treatment of Efractory Recurrent Multiple Myeloma

Sponsor

Changzhou No.2 People's Hospital

Status

UNKNOWN

Phase

Early Phase 1

Condition raw

Multiple Myeloma

Condition normalized

Multiple Myeloma

Modality raw

small molecule

Modality normalized

small molecule

Target raw

NKG2D receptor on NK cells, targeting NKG2D ligands (NKG2DL) expressed on tumor cells.

Target normalized

NKG2D receptor on NK cells, targeting NKG2D ligands (NKG2DL) expressed on tumor cells.

Interventions

NKG2D Chimeric Antigen Receptor NK Cell Injection

Public preview

Source record

The exploratory study sponsored by Changzhou No.2 People's Hospital aims to evaluate the safety and efficacy of NKG2D CAR-NK cell injections for treating refractory recurrent multiple myeloma (MM). Given the increasing incidence of MM and the limitations of current therapies, including CAR-T cell therapy, this approach may address a significant unmet medical need. The market for MM therapies is expanding, with a focus on innovative cell therapies. If successful, this asset could position itself as a competitive alternative to existing treatments, particularly in patients with relapsed/refractory disease who are not candidates for traditional therapies. The trial's outcomes could influence future development strategies and partnerships in the immunotherapy landscape.

AI-generated analysis supports research triage only. Verify source records, publications, sponsor disclosures and IP databases before making diligence decisions. Model: trialsignal-ai-v1.

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