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NCT03788603COMPLETEDanonymous

An Open Label, Phase 1 Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Rogaratinib (BAY1163877) in Chinese Patients With FGFR-positive Refractory, Locally Advanced, or Metastatic Solid Tumors

Sponsor

Source record

Bayer

Phase

Source record

Phase 1

Modality

AI-normalized

small molecule

Target

AI-normalized

Fibroblast Growth Factor Receptors (FGFR1, 2, 3, 4)

Indication / condition

AI-normalized

Neoplasms

Intervention

Source record

Rogaratinib (BAY1163877)

Source & freshness

Source record

NCT ID

NCT03788603

Original source

ClinicalTrials.gov

Source last updated

Mar 29, 2021

Ingested at

Jun 17, 2026

Internal sync

Jun 17, 2026

Model version

trialsignal-ai-v1

Normalized confidence

96%

Validation status

validated

Open original registry record
View original source fields

NCT ID

NCT03788603

Title

An Open Label, Phase 1 Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Rogaratinib (BAY1163877) in Chinese Patients With FGFR-positive Refractory, Locally Advanced, or Metastatic Solid Tumors

Sponsor

Bayer

Status

COMPLETED

Phase

Phase 1

Condition raw

Neoplasms

Condition normalized

Neoplasms

Modality raw

small molecule

Modality normalized

small molecule

Target raw

Fibroblast Growth Factor Receptors (FGFR1, 2, 3, 4)

Target normalized

Fibroblast Growth Factor Receptors (FGFR1, 2, 3, 4)

Interventions

Rogaratinib (BAY1163877)

Public preview

Source record

Rogaratinib (BAY1163877) is being evaluated for safety and pharmacokinetics in Chinese patients with FGFR-positive refractory, locally advanced, or metastatic solid tumors. The focus on a specific patient population with high FGFR expression levels may position Bayer favorably in the targeted therapy market, particularly in oncology. Given the increasing emphasis on precision medicine, successful outcomes could enhance Bayer's portfolio in the competitive landscape of FGFR inhibitors, which includes other agents currently in development or on the market. The completion of this trial may also provide valuable data for future regulatory submissions and broaden the therapeutic indications for rogaratinib, potentially increasing its market share.

AI-generated analysis supports research triage only. Verify source records, publications, sponsor disclosures and IP databases before making diligence decisions. Model: trialsignal-ai-v1.

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