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NCT07564453RECRUITINGanonymous

Full-course Immunotherapy Combined With Chemotherapy in Newly Diagnosed B-cell Acute Lymphoblastic Leukemia

Sponsor

Source record

The First Affiliated Hospital of Soochow University

Phase

Source record

Phase 2

Modality

AI-normalized

protein therapy

Target

AI-normalized

CD19 (targeted by blinatumomab and CD19-directed CAR-T therapy)

Indication / condition

AI-normalized

B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative

Intervention

Source record

Blinatumomab, Induction Chemotherapy, Hyper-CVAD, Allogeneic hematopoietic stem cell transplantation, CAR-T cell therapy

Source & freshness

Source record

NCT ID

NCT07564453

Original source

ClinicalTrials.gov

Source last updated

May 04, 2026

Ingested at

Jun 17, 2026

Internal sync

Jun 17, 2026

Model version

trialsignal-ai-v1

Normalized confidence

96%

Validation status

validated

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NCT ID

NCT07564453

Title

Full-course Immunotherapy Combined With Chemotherapy in Newly Diagnosed B-cell Acute Lymphoblastic Leukemia

Sponsor

The First Affiliated Hospital of Soochow University

Status

RECRUITING

Phase

Phase 2

Condition raw

B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative

Condition normalized

B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative

Modality raw

protein therapy

Modality normalized

protein therapy

Target raw

CD19 (targeted by blinatumomab and CD19-directed CAR-T therapy)

Target normalized

CD19 (targeted by blinatumomab and CD19-directed CAR-T therapy)

Interventions

Blinatumomab, Induction Chemotherapy, Hyper-CVAD, Allogeneic hematopoietic stem cell transplantation, CAR-T cell therapy

Public preview

Source record

This clinical trial, sponsored by The First Affiliated Hospital of Soochow University, aims to evaluate the efficacy of a novel treatment regimen combining blinatumomab with reduced-dose chemotherapy in patients with newly diagnosed Philadelphia chromosome-negative B-cell acute lymphoblastic leukemia (B-ALL). The market for B-ALL therapies is competitive, with existing treatments including traditional chemotherapy and emerging immunotherapies. Successful outcomes could position this regimen favorably against current standards, potentially leading to enhanced market share and revenue opportunities. Given the trial's focus on improving survival rates and tolerability, it may attract interest from investors and pharmaceutical companies looking to expand their oncology portfolios. Diligence should consider the regulatory landscape, potential for expedited approvals, and the need for robust post-marketing studies if successful.

AI-generated analysis supports research triage only. Verify source records, publications, sponsor disclosures and IP databases before making diligence decisions. Model: trialsignal-ai-v1.

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