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NCT07454122NOT_YET_RECRUITINGanonymous

Off-the-shelf CD5CAR-NK Cells for Refractory Invasive Mold Disease: Phase I Clinical Trial.

Sponsor

Source record

Fundacion Clinic per a la Recerca Biomédica

Phase

Source record

Phase 1

Modality

AI-normalized

gene therapy

Target

AI-normalized

CD5 receptor (CD5) on allogeneic natural killer (NK) cells

Indication / condition

AI-normalized

Fungal Infection

Intervention

Source record

CD5CAR-CBNK

Source & freshness

Source record

NCT ID

NCT07454122

Original source

ClinicalTrials.gov

Source last updated

Mar 06, 2026

Ingested at

Jun 17, 2026

Internal sync

Jun 17, 2026

Model version

trialsignal-ai-v1

Normalized confidence

96%

Validation status

validated

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View original source fields

NCT ID

NCT07454122

Title

Off-the-shelf CD5CAR-NK Cells for Refractory Invasive Mold Disease: Phase I Clinical Trial.

Sponsor

Fundacion Clinic per a la Recerca Biomédica

Status

NOT_YET_RECRUITING

Phase

Phase 1

Condition raw

Fungal Infection

Condition normalized

Fungal Infection

Modality raw

gene therapy

Modality normalized

gene therapy

Target raw

CD5 receptor (CD5) on allogeneic natural killer (NK) cells

Target normalized

CD5 receptor (CD5) on allogeneic natural killer (NK) cells

Interventions

CD5CAR-CBNK

Public preview

Source record

The CD5CAR-NK cells represent a novel therapeutic approach for refractory invasive mold disease (IMD), a condition with limited treatment options and high mortality rates. The market for antifungal therapies is growing, driven by increasing incidences of fungal infections, particularly in immunocompromised patients. If successful, CD5CAR-NK could position itself as a first-line or adjunctive therapy in this niche market, potentially leading to significant commercial opportunities. The trial's single-site design may limit initial scalability, but successful outcomes could attract partnerships or acquisitions from larger biopharma companies seeking to enhance their portfolios in immunotherapy and infectious diseases. Competitive landscape analysis reveals limited direct competition in CAR-NK cell therapies specifically targeting fungal infections, suggesting a unique market position if safety and efficacy are established.

AI-generated analysis supports research triage only. Verify source records, publications, sponsor disclosures and IP databases before making diligence decisions. Model: trialsignal-ai-v1.

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