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NCT02932956ACTIVE_NOT_RECRUITINGanonymous

Glypican 3-specific Chimeric Antigen Receptor Expressed in Autologous T Cells as Immunotherapy for Patients With Pediatric Solid Tumors

Sponsor

Source record

Baylor College of Medicine

Phase

Source record

Phase 1

Modality

AI-normalized

gene therapy

Target

AI-normalized

Glypican-3 (GPC3), a proteoglycan expressed on solid tumors, particularly pediatric liver cancers.

Indication / condition

AI-normalized

Liver Cancer

Intervention

Source record

GAP T cells, Cytoxan, Fludara

Source & freshness

Source record

NCT ID

NCT02932956

Original source

ClinicalTrials.gov

Source last updated

Sep 19, 2025

Ingested at

Jun 17, 2026

Internal sync

Jun 17, 2026

Model version

trialsignal-ai-v1

Normalized confidence

96%

Validation status

validated

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NCT ID

NCT02932956

Title

Glypican 3-specific Chimeric Antigen Receptor Expressed in Autologous T Cells as Immunotherapy for Patients With Pediatric Solid Tumors

Sponsor

Baylor College of Medicine

Status

ACTIVE_NOT_RECRUITING

Phase

Phase 1

Condition raw

Liver Cancer

Condition normalized

Liver Cancer

Modality raw

gene therapy

Modality normalized

gene therapy

Target raw

Glypican-3 (GPC3), a proteoglycan expressed on solid tumors, particularly pediatric liver cancers.

Target normalized

Glypican-3 (GPC3), a proteoglycan expressed on solid tumors, particularly pediatric liver cancers.

Interventions

GAP T cells, Cytoxan, Fludara

Public preview

Source record

The GAP T cells represent a novel immunotherapeutic approach targeting GPC3-positive solid tumors in pediatric patients. Given the limited treatment options for relapsed or refractory pediatric liver cancers, this asset addresses a significant unmet medical need. The potential for successful outcomes could position Baylor College of Medicine as a leader in pediatric oncology therapies, particularly in CAR T-cell innovations. The investigational nature of the therapy and its current FDA status as unapproved necessitate careful navigation of regulatory pathways and potential partnerships for commercialization. Competitively, the asset may face challenges from other CAR T-cell therapies and immunotherapies targeting similar tumor markers, necessitating robust clinical data to establish efficacy and safety profiles.

AI-generated analysis supports research triage only. Verify source records, publications, sponsor disclosures and IP databases before making diligence decisions. Model: trialsignal-ai-v1.

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