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Clinical trial intelligence report
Glypican 3-specific Chimeric Antigen Receptor Expressed in Autologous T Cells as Immunotherapy for Patients With Pediatric Solid Tumors
Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.
Generated
Jun 17, 2026
NCT ID
NCT02932956
Status
ACTIVE_NOT_RECRUITING
Phase
Phase 1
Sponsor
Baylor College of Medicine
Executive brief
Investment-Ready Snapshot
The GAP T cells represent a novel immunotherapeutic approach targeting GPC3-positive solid tumors in pediatric patients. Given the limited treatment options for relapsed or refractory pediatric liver cancers, this asset addresses a significant unmet medical need. The potential for successful outcomes could position Baylor College of Medicine as a leader in pediatric oncology therapies, particularly in CAR T-cell innovations. The investigational nature of the therapy and its current FDA status as unapproved necessitate careful navigation of regulatory pathways and potential partnerships for commercialization. Competitively, the asset may face challenges from other CAR T-cell therapies and immunotherapies targeting similar tumor markers, necessitating robust clinical data to establish efficacy and safety profiles.
Source & freshness
Provenance
https://clinicaltrials.gov/study/NCT02932956
Indication
Liver Cancer
Modality
gene therapy
Target
Glypican-3 (GPC3), a proteoglycan expressed on solid tumors, particularly pediatric liver cancers.
Intervention
GAP T cells, Cytoxan, Fludara
Source record
Protocol Description
Detailed source ingestion pending.
Source record
Outcome Measures
Detailed source ingestion pending.
Source record
Eligibility
Detailed source ingestion pending.
AI analysis
Known Results And Readout Context
Detailed source ingestion pending.
IP intelligence
Patent And IP Landscape
Detailed source ingestion pending.
Source record
Contacts
Detailed source ingestion pending.