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NCT02937103UNKNOWNanonymous

A Clinical Research of CD123-Targeted CAR-T in Myeloid Malignancies

Sponsor

Source record

Southwest Hospital, China

Phase

Source record

Phase 1/2

Modality

AI-normalized

cell therapy

Target

AI-normalized

CD123-targeted chimeric antigen receptor (CAR) T cells

Indication / condition

AI-normalized

Leukemia

Intervention

Source record

Anti-CD123-CAR-transduced T cells

Source & freshness

Source record

NCT ID

NCT02937103

Original source

ClinicalTrials.gov

Source last updated

Jun 25, 2019

Ingested at

Jun 17, 2026

Internal sync

Jun 17, 2026

Model version

trialsignal-ai-v1

Normalized confidence

96%

Validation status

validated

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View original source fields

NCT ID

NCT02937103

Title

A Clinical Research of CD123-Targeted CAR-T in Myeloid Malignancies

Sponsor

Southwest Hospital, China

Status

UNKNOWN

Phase

Phase 1/2

Condition raw

Leukemia

Condition normalized

Leukemia

Modality raw

cell therapy

Modality normalized

cell therapy

Target raw

CD123-targeted chimeric antigen receptor (CAR) T cells

Target normalized

CD123-targeted chimeric antigen receptor (CAR) T cells

Interventions

Anti-CD123-CAR-transduced T cells

Public preview

Source record

The clinical trial, sponsored by Southwest Hospital in China, focuses on the therapeutic potential of CD123-targeted CAR-T cells for treating myeloid malignancies, which currently lack effective treatment options for relapsed or refractory cases. The trial aims to address a significant unmet medical need in the oncology market, particularly for patients ineligible for allogeneic stem cell transplantation. Given the promising results seen with CD19-targeted CAR-T therapies in B cell malignancies, this trial could position the sponsor as a key player in the CAR-T space for myeloid cancers, potentially leading to lucrative partnerships or acquisition interest from larger biopharmaceutical companies. The estimated enrollment of 45 patients and the focus on safety and efficacy will be critical for future commercialization strategies.

AI-generated analysis supports research triage only. Verify source records, publications, sponsor disclosures and IP databases before making diligence decisions. Model: trialsignal-ai-v1.

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