Report workspace

Add to folder
NCT01462227COMPLETEDanonymous

The Effect of Opiate Blockade With Naltrexone on Counterregulatory Mechanisms in Hypoglycemia

Sponsor

Source record

Yale University

Phase

Source record

Not Applicable

Modality

AI-normalized

small molecule

Target

AI-normalized

Opiate receptors (specifically mu-opioid receptors) involved in counterregulatory hormone release during hypoglycemia.

Indication / condition

AI-normalized

Hypoglycemia

Intervention

Source record

Naltrexone High Dose, Naltrexone Low Dose

Source & freshness

Source record

NCT ID

NCT01462227

Original source

ClinicalTrials.gov

Source last updated

Feb 18, 2016

Ingested at

Jun 17, 2026

Internal sync

Jun 17, 2026

Model version

trialsignal-ai-v1

Normalized confidence

96%

Validation status

validated

Open original registry record
View original source fields

NCT ID

NCT01462227

Title

The Effect of Opiate Blockade With Naltrexone on Counterregulatory Mechanisms in Hypoglycemia

Sponsor

Yale University

Status

COMPLETED

Phase

Not Applicable

Condition raw

Hypoglycemia

Condition normalized

Hypoglycemia

Modality raw

small molecule

Modality normalized

small molecule

Target raw

Opiate receptors (specifically mu-opioid receptors) involved in counterregulatory hormone release during hypoglycemia.

Target normalized

Opiate receptors (specifically mu-opioid receptors) involved in counterregulatory hormone release during hypoglycemia.

Interventions

Naltrexone High Dose, Naltrexone Low Dose

Public preview

Source record

The study investigates the use of naltrexone, a known opioid receptor antagonist, to enhance recovery from hypoglycemia in patients with type 1 diabetes. Given the lack of current therapeutic options for managing hypoglycemia recovery, a successful outcome could position naltrexone as a novel treatment in the diabetes care market. The potential to address a significant unmet medical need could attract interest from pharmaceutical companies specializing in diabetes management. However, the competitive landscape includes ongoing research into alternative therapies for hypoglycemia, necessitating thorough diligence on market entry strategies and potential partnerships.

AI-generated analysis supports research triage only. Verify source records, publications, sponsor disclosures and IP databases before making diligence decisions. Model: trialsignal-ai-v1.

Report access

Create an account to unlock this report

Choose the access model that matches the job: one urgent report, reusable credits for project work, or unlimited monthly access with AI and folders.

Full protocol, outcomes, eligibility, contacts and results sections
Patent/IP landscape with verified records when available
Board-ready PDF export with source provenance
Save to folders and synthesize multiple assets in premium workspace
Create account

Create a free account first, then unlock a single report, buy credits or subscribe.