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NCT02943850COMPLETEDanonymous

Human Neural Progenitor Cells Secreting Glial Cell Line-Derived Neurotrophic Factor (CNS10-NPC-GDNF) for the Treatment of Amyotrophic Lateral Sclerosis

Sponsor

Source record

Cedars-Sinai Medical Center

Phase

Source record

PHASE1

Modality

AI-normalized

cell therapy

Target

AI-normalized

Stem cell (HPC) implantation, Stereotactic surgical device

Indication / condition

AI-normalized

Amyotrophic Lateral Sclerosis

Intervention

Source record

Stem cell (HPC) implantation, Stereotactic surgical device

Source & freshness

Source record

NCT ID

NCT02943850

Original source

ClinicalTrials.gov

Source last updated

Jul 15, 2020

Ingested at

Jun 16, 2026

Internal sync

Jun 16, 2026

Model version

trialsignal-ai-v1

Normalized confidence

96%

Validation status

validated

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View original source fields

NCT ID

NCT02943850

Title

Human Neural Progenitor Cells Secreting Glial Cell Line-Derived Neurotrophic Factor (CNS10-NPC-GDNF) for the Treatment of Amyotrophic Lateral Sclerosis

Sponsor

Cedars-Sinai Medical Center

Status

COMPLETED

Phase

PHASE1

Condition raw

Amyotrophic Lateral Sclerosis

Condition normalized

Amyotrophic Lateral Sclerosis

Modality raw

cell therapy

Modality normalized

cell therapy

Target raw

Stem cell (HPC) implantation, Stereotactic surgical device

Target normalized

Stem cell (HPC) implantation, Stereotactic surgical device

Interventions

Stem cell (HPC) implantation, Stereotactic surgical device

Public preview

Source record

The investigator is examining the safety of transplanting cells that have been engineered to produce a growth factor into the spinal cord of patients with Amyotrophic Lateral Sclerosis (ALS). The cells are called neural progenitor cells, which are a type of stem cell that can become several different types of cells in the nervous system. These cells have been derived to specifically become astrocytes, which is a type of neuronal cell. The growth factor is called glial cell line-derived neurotrophic factor, or GDNF. GDNF is a protein that promotes the survival of many types of neuronal cells. Therefore, the cells are called "CNS10-NPC-GDNF." The investigational treatment has been tested in animals, but it has not yet been tested in people. In this study, we want to learn if CNS10-NPC-GDNF cells are safe to transplant into the spinal cords of people.

AI-generated analysis supports research triage only. Verify source records, publications, sponsor disclosures and IP databases before making diligence decisions. Model: trialsignal-ai-v1.

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