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NCT03150290COMPLETEDanonymous

Energy Expenditure and Brown Adipose Tissue in Amyotrophic Lateral Sclerosis

Sponsor

Source record

Institut National de la Santé Et de la Recherche Médicale, France

Phase

Source record

NA

Modality

AI-normalized

medical device

Target

AI-normalized

Indirect Calorimetry., 18-FDG-PET

Indication / condition

AI-normalized

Amyotrophic Lateral Sclerosis

Intervention

Source record

Indirect Calorimetry., 18-FDG-PET

Source & freshness

Source record

NCT ID

NCT03150290

Original source

ClinicalTrials.gov

Source last updated

Aug 26, 2021

Ingested at

Jun 16, 2026

Internal sync

Jun 16, 2026

Model version

trialsignal-ai-v1

Normalized confidence

96%

Validation status

validated

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View original source fields

NCT ID

NCT03150290

Title

Energy Expenditure and Brown Adipose Tissue in Amyotrophic Lateral Sclerosis

Sponsor

Institut National de la Santé Et de la Recherche Médicale, France

Status

COMPLETED

Phase

NA

Condition raw

Amyotrophic Lateral Sclerosis

Condition normalized

Amyotrophic Lateral Sclerosis

Modality raw

medical device

Modality normalized

medical device

Target raw

Indirect Calorimetry., 18-FDG-PET

Target normalized

Indirect Calorimetry., 18-FDG-PET

Interventions

Indirect Calorimetry., 18-FDG-PET

Public preview

Source record

Weight loss is a common phenomenon in ALS. During the course of the disease, difficulty in swallowing and mastication can be responsible for a decrease in caloric intake and thus for weight loss. However, significant weight loss can also be observed in patients with no feeding difficulties. About half of ALS patients have an increase in their resting energy consumption, but the origin of this "hypermetabolism" remains unknown. "Brown" fat is specialized in the production of heat. Unlike "white" fat that stores excess caloric intakes, brown fat consumes energy. In humans, brown fat has long been considered as absent in adults. However, recent imaging techniques have been able to detect brown fat deposits in some adult subjects. The aim of this study is thus to determine the role of brown fat on energy consumption in Amyotrophic Lateral Sclerosis.

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