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NCT03913312UNKNOWNanonymous

Multicenter, One-arm, Phase II Clinical Study of Decitabine Combined With Unrelated Cord Blood Transplantation for the Treatment of Acute Myeloid Leukemia (AML) in the Elderly

Sponsor

Source record

Ruijin Hospital

Phase

Source record

Phase 2

Modality

AI-normalized

protein therapy

Target

AI-normalized

Decitabine (DAC) and cytarabine in combination with unrelated cord blood transplantation for the treatment of acute myeloid leukemia (AML) in elderly patients.

Indication / condition

AI-normalized

Acute Myeloid Leukemia

Intervention

Source record

Unrelated cord blood

Source & freshness

Source record

NCT ID

NCT03913312

Original source

ClinicalTrials.gov

Source last updated

Jul 23, 2019

Ingested at

Jun 16, 2026

Internal sync

Jun 16, 2026

Model version

trialsignal-ai-v1

Normalized confidence

96%

Validation status

validated

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NCT ID

NCT03913312

Title

Multicenter, One-arm, Phase II Clinical Study of Decitabine Combined With Unrelated Cord Blood Transplantation for the Treatment of Acute Myeloid Leukemia (AML) in the Elderly

Sponsor

Ruijin Hospital

Status

UNKNOWN

Phase

Phase 2

Condition raw

Acute Myeloid Leukemia

Condition normalized

Acute Myeloid Leukemia

Modality raw

protein therapy

Modality normalized

protein therapy

Target raw

Decitabine (DAC) and cytarabine in combination with unrelated cord blood transplantation for the treatment of acute myeloid leukemia (AML) in elderly patients.

Target normalized

Decitabine (DAC) and cytarabine in combination with unrelated cord blood transplantation for the treatment of acute myeloid leukemia (AML) in elderly patients.

Interventions

Unrelated cord blood

Public preview

Source record

This Phase II trial, sponsored by Ruijin Hospital, aims to evaluate the efficacy and safety of a novel treatment regimen combining decitabine and cytarabine with unrelated cord blood transplantation in elderly patients with AML. Given the aging population and the high unmet medical need in this demographic, successful outcomes could position this therapy favorably in a competitive market. The trial's focus on a vulnerable patient population (aged 60-75) highlights potential for market differentiation. However, the absence of FDA regulation may limit immediate commercial viability in certain markets. The results could attract interest from larger biopharmaceutical companies for potential partnerships or acquisitions, especially if the regimen demonstrates superior outcomes compared to traditional therapies.

AI-generated analysis supports research triage only. Verify source records, publications, sponsor disclosures and IP databases before making diligence decisions. Model: trialsignal-ai-v1.

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