TrialSignal
Clinical trial intelligence report
Glutamatergic Dysfunction in Cognitive Aging: Riluzole in Mild Alzheimer's Disease
Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.
Generated
Jun 16, 2026
NCT ID
NCT01703117
Status
COMPLETED
Phase
Phase 2
Sponsor
Icahn School of Medicine at Mount Sinai
Executive brief
Investment-Ready Snapshot
The trial, sponsored by the Icahn School of Medicine at Mount Sinai, investigates Riluzole's efficacy in treating mild Alzheimer's disease, a significant unmet medical need given the increasing prevalence of cognitive aging disorders. The study's completion and the use of established biomarkers (FDG-PET and MRS) enhance its credibility and potential for future commercialization. If successful, Riluzole could position itself as a novel therapeutic option in a market dominated by acetylcholinesterase inhibitors and other symptomatic treatments. The competitive landscape includes ongoing research into disease-modifying therapies, which may impact market entry strategies and pricing. Diligence should focus on the trial's results and the potential for further studies to validate findings and secure regulatory approval.
Source & freshness
Provenance
https://clinicaltrials.gov/study/NCT01703117
Indication
Alzheimer's Disease
Modality
small molecule
Target
Glutamate modulation via Riluzole, aimed at reducing glutamate-mediated excitotoxicity in Alzheimer's disease.
Intervention
Riluzole, Placebo
Source record
Protocol Description
Detailed source ingestion pending.
Source record
Outcome Measures
Detailed source ingestion pending.
Source record
Eligibility
Detailed source ingestion pending.
AI analysis
Known Results And Readout Context
Detailed source ingestion pending.
IP intelligence
Patent And IP Landscape
Detailed source ingestion pending.
Source record
Contacts
Detailed source ingestion pending.