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NCT07318818RECRUITINGanonymous

A Phase I/II Clinical Study to Evaluate the Safety and Efficacy of P134 Cells in the Treatment of Recurrent Glioblastoma

Sponsor

Source record

Tasly Pharmaceutical Group Co., Ltd

Phase

Source record

Phase 1/2

Modality

AI-normalized

protein therapy

Target

AI-normalized

CD44 and CD133 dual-targeting CAR-T cells

Indication / condition

AI-normalized

Recurrent Glioblastoma IDH Wildtype

Intervention

Source record

P134 cell injection

Source & freshness

Source record

NCT ID

NCT07318818

Original source

ClinicalTrials.gov

Source last updated

Feb 18, 2026

Ingested at

Jun 16, 2026

Internal sync

Jun 16, 2026

Model version

trialsignal-ai-v1

Normalized confidence

96%

Validation status

validated

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NCT ID

NCT07318818

Title

A Phase I/II Clinical Study to Evaluate the Safety and Efficacy of P134 Cells in the Treatment of Recurrent Glioblastoma

Sponsor

Tasly Pharmaceutical Group Co., Ltd

Status

RECRUITING

Phase

Phase 1/2

Condition raw

Recurrent Glioblastoma IDH Wildtype

Condition normalized

Recurrent Glioblastoma IDH Wildtype

Modality raw

protein therapy

Modality normalized

protein therapy

Target raw

CD44 and CD133 dual-targeting CAR-T cells

Target normalized

CD44 and CD133 dual-targeting CAR-T cells

Interventions

P134 cell injection

Public preview

Source record

Tasly Pharmaceutical Group's P134 cells represent a novel approach in the treatment of recurrent glioblastoma, targeting CD44 and CD133 antigens. Given the high unmet medical need in this indication, the asset has significant commercial potential. The market for glioblastoma therapies is competitive, with established treatments like temozolomide and emerging immunotherapies. Successful outcomes in this trial could position Tasly favorably against competitors, particularly if P134 demonstrates superior efficacy or safety profiles. Diligence is warranted to assess the scalability of manufacturing CAR-T cells and the regulatory pathway in various jurisdictions, particularly in light of evolving CAR-T therapy regulations.

AI-generated analysis supports research triage only. Verify source records, publications, sponsor disclosures and IP databases before making diligence decisions. Model: trialsignal-ai-v1.

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