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NCT06075667ACTIVE_NOT_RECRUITINGanonymous

Efficacy, Safety, and Pharmacokinetics of Tirzepatide Once Weekly Versus Placebo in Adolescent Participants Who Have Obesity, or Are Overweight With Weight-Related Comorbidities: A Randomized, Double-Blind Trial (SURMOUNT-ADOLESCENTS)

Sponsor

Source record

Eli Lilly and Company

Phase

Source record

Phase 3

Modality

AI-normalized

small molecule

Target

AI-normalized

GLP-1 receptor and GIP receptor agonist

Indication / condition

AI-normalized

Obesity

Intervention

Source record

Tirzepatide, Placebo

Source & freshness

Source record

NCT ID

NCT06075667

Original source

ClinicalTrials.gov

Source last updated

Jun 25, 2025

Ingested at

Jun 16, 2026

Internal sync

Jun 16, 2026

Model version

trialsignal-ai-v1

Normalized confidence

96%

Validation status

validated

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NCT ID

NCT06075667

Title

Efficacy, Safety, and Pharmacokinetics of Tirzepatide Once Weekly Versus Placebo in Adolescent Participants Who Have Obesity, or Are Overweight With Weight-Related Comorbidities: A Randomized, Double-Blind Trial (SURMOUNT-ADOLESCENTS)

Sponsor

Eli Lilly and Company

Status

ACTIVE_NOT_RECRUITING

Phase

Phase 3

Condition raw

Obesity, Overweight

Condition normalized

Obesity, Overweight

Modality raw

small molecule

Modality normalized

small molecule

Target raw

GLP-1 receptor and GIP receptor agonist

Target normalized

GLP-1 receptor and GIP receptor agonist

Interventions

Tirzepatide, Placebo

Public preview

Source record

Eli Lilly's tirzepatide is currently being evaluated in a Phase 3 clinical trial (SURMOUNT-ADOLESCENTS) targeting adolescents with obesity or overweight conditions, particularly those with weight-related comorbidities. The trial's focus on a younger demographic represents a strategic expansion of tirzepatide's market potential, given the rising prevalence of obesity in adolescents. The competitive landscape includes other obesity treatments, particularly those targeting GLP-1 and GIP pathways, such as Novo Nordisk's semaglutide. Successful outcomes could position Eli Lilly favorably in the pediatric obesity market, which is increasingly recognized as a critical area for intervention. The trial's design includes a long treatment duration and multiple endpoints, which may enhance the robustness of the data and support regulatory submissions. However, the market will require careful monitoring of competitor developments and potential pricing strategies post-approval.

AI-generated analysis supports research triage only. Verify source records, publications, sponsor disclosures and IP databases before making diligence decisions. Model: trialsignal-ai-v1.

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