TrialSignal
Clinical trial intelligence report
A Phase II, Single-Arm, Study of Elotuzumab, Selinexor, and Dexamethasone in Patients With Relapsed Refractory Multiple Myeloma
Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.
Generated
Jun 16, 2026
NCT ID
NCT05170789
Status
WITHDRAWN
Phase
Phase 2
Sponsor
Tulane University School of Medicine
Executive brief
Investment-Ready Snapshot
The clinical trial, sponsored by Tulane University School of Medicine, aimed to evaluate the combination of Elotuzumab, Selinexor, and Dexamethasone in patients with relapsed refractory multiple myeloma (RRMM). Despite the promising mechanism of action involving immune modulation and apoptosis induction, the study was withdrawn due to lack of funding from collaborator Karyopharm Therapeutics. The market for RRMM treatments is competitive, with several approved therapies, including Selinexor and Elotuzumab, already in use. The withdrawal of this trial may impact Tulane's positioning in the market and their ability to attract future collaborations or funding for similar studies.
Source & freshness
Provenance
https://clinicaltrials.gov/study/NCT05170789
Indication
Relapsed Multiple Myeloma
Modality
small molecule
Target
Exportin 1 (XPO1) and SLAMF7
Intervention
Elotuzumab, Selinexor, and Dexamethasone (ESd)
Source record
Protocol Description
Detailed source ingestion pending.
Source record
Outcome Measures
Detailed source ingestion pending.
Source record
Eligibility
Detailed source ingestion pending.
AI analysis
Known Results And Readout Context
Detailed source ingestion pending.
IP intelligence
Patent And IP Landscape
Detailed source ingestion pending.
Source record
Contacts
Detailed source ingestion pending.