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NCT05170789WITHDRAWNanonymous

A Phase II, Single-Arm, Study of Elotuzumab, Selinexor, and Dexamethasone in Patients With Relapsed Refractory Multiple Myeloma

Sponsor

Source record

Tulane University School of Medicine

Phase

Source record

Phase 2

Modality

AI-normalized

small molecule

Target

AI-normalized

Exportin 1 (XPO1) and SLAMF7

Indication / condition

AI-normalized

Relapsed Multiple Myeloma

Intervention

Source record

Elotuzumab, Selinexor, and Dexamethasone (ESd)

Source & freshness

Source record

NCT ID

NCT05170789

Original source

ClinicalTrials.gov

Source last updated

May 04, 2022

Ingested at

Jun 13, 2026

Internal sync

Jun 13, 2026

Model version

trialsignal-ai-v1

Normalized confidence

96%

Validation status

validated

Open original registry record
View original source fields

NCT ID

NCT05170789

Title

A Phase II, Single-Arm, Study of Elotuzumab, Selinexor, and Dexamethasone in Patients With Relapsed Refractory Multiple Myeloma

Sponsor

Tulane University School of Medicine

Status

WITHDRAWN

Phase

Phase 2

Condition raw

Relapsed Multiple Myeloma, Refractory Multiple Myeloma

Condition normalized

Relapsed Multiple Myeloma, Refractory Multiple Myeloma

Modality raw

small molecule

Modality normalized

small molecule

Target raw

Exportin 1 (XPO1) and SLAMF7

Target normalized

Exportin 1 (XPO1) and SLAMF7

Interventions

Elotuzumab, Selinexor, and Dexamethasone (ESd)

Public preview

Source record

The clinical trial, sponsored by Tulane University School of Medicine, aimed to evaluate the combination of Elotuzumab, Selinexor, and Dexamethasone in patients with relapsed refractory multiple myeloma (RRMM). Despite the promising mechanism of action involving immune modulation and apoptosis induction, the study was withdrawn due to lack of funding from collaborator Karyopharm Therapeutics. The market for RRMM treatments is competitive, with several approved therapies, including Selinexor and Elotuzumab, already in use. The withdrawal of this trial may impact Tulane's positioning in the market and their ability to attract future collaborations or funding for similar studies.

AI-generated analysis supports research triage only. Verify source records, publications, sponsor disclosures and IP databases before making diligence decisions. Model: trialsignal-ai-v1.

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