TrialSignal
Clinical trial intelligence report
A Single-Dose, Double-Blind, Crossover, Placebo- and Moxifloxacin (Open-Label)-Controlled Study of the Effects of Lecozotan SR on Cardiac Repolarization in Healthy Adult Subjects
Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.
Generated
Jun 16, 2026
NCT ID
NCT00499642
Status
COMPLETED
Phase
Phase 1
Sponsor
Wyeth is now a wholly owned subsidiary of Pfizer
Executive brief
Investment-Ready Snapshot
This Phase 1 clinical trial, sponsored by Wyeth (a subsidiary of Pfizer), investigates the effects of Lecozotan SR on cardiac repolarization in healthy adults. The study's completion in August 2007 indicates that the asset has progressed through initial safety and pharmacokinetic evaluations. Given the increasing focus on cardiac safety in drug development, particularly for CNS-active compounds, Lecozotan SR may have potential applications in treating conditions like Alzheimer's disease, where cardiac safety is paramount. The competitive landscape includes other 5-HT1A antagonists, and successful outcomes could position Lecozotan SR favorably in the market, especially if it demonstrates a favorable safety profile compared to existing therapies.
Source & freshness
Provenance
https://clinicaltrials.gov/study/NCT00499642
Indication
Alzheimer Disease
Modality
small molecule
Target
Lecozotan SR is a selective antagonist of the 5-HT1A receptor, which is implicated in the modulation of cardiac repolarization.
Intervention
Lecozotan SR, Moxifloxacin
Source record
Protocol Description
Detailed source ingestion pending.
Source record
Outcome Measures
Detailed source ingestion pending.
Source record
Eligibility
Detailed source ingestion pending.
AI analysis
Known Results And Readout Context
Detailed source ingestion pending.
IP intelligence
Patent And IP Landscape
Detailed source ingestion pending.
Source record
Contacts
Detailed source ingestion pending.