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NCT00499642COMPLETEDanonymous

A Single-Dose, Double-Blind, Crossover, Placebo- and Moxifloxacin (Open-Label)-Controlled Study of the Effects of Lecozotan SR on Cardiac Repolarization in Healthy Adult Subjects

Sponsor

Source record

Wyeth is now a wholly owned subsidiary of Pfizer

Phase

Source record

Phase 1

Modality

AI-normalized

small molecule

Target

AI-normalized

Lecozotan SR is a selective antagonist of the 5-HT1A receptor, which is implicated in the modulation of cardiac repolarization.

Indication / condition

AI-normalized

Alzheimer Disease

Intervention

Source record

Lecozotan SR, Moxifloxacin

Source & freshness

Source record

NCT ID

NCT00499642

Original source

ClinicalTrials.gov

Source last updated

Dec 28, 2007

Ingested at

Jun 13, 2026

Internal sync

Jun 13, 2026

Model version

trialsignal-ai-v1

Normalized confidence

96%

Validation status

validated

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NCT ID

NCT00499642

Title

A Single-Dose, Double-Blind, Crossover, Placebo- and Moxifloxacin (Open-Label)-Controlled Study of the Effects of Lecozotan SR on Cardiac Repolarization in Healthy Adult Subjects

Sponsor

Wyeth is now a wholly owned subsidiary of Pfizer

Status

COMPLETED

Phase

Phase 1

Condition raw

Alzheimer Disease, Healthy

Condition normalized

Alzheimer Disease, Healthy

Modality raw

small molecule

Modality normalized

small molecule

Target raw

Lecozotan SR is a selective antagonist of the 5-HT1A receptor, which is implicated in the modulation of cardiac repolarization.

Target normalized

Lecozotan SR is a selective antagonist of the 5-HT1A receptor, which is implicated in the modulation of cardiac repolarization.

Interventions

Lecozotan SR, Moxifloxacin

Public preview

Source record

This Phase 1 clinical trial, sponsored by Wyeth (a subsidiary of Pfizer), investigates the effects of Lecozotan SR on cardiac repolarization in healthy adults. The study's completion in August 2007 indicates that the asset has progressed through initial safety and pharmacokinetic evaluations. Given the increasing focus on cardiac safety in drug development, particularly for CNS-active compounds, Lecozotan SR may have potential applications in treating conditions like Alzheimer's disease, where cardiac safety is paramount. The competitive landscape includes other 5-HT1A antagonists, and successful outcomes could position Lecozotan SR favorably in the market, especially if it demonstrates a favorable safety profile compared to existing therapies.

AI-generated analysis supports research triage only. Verify source records, publications, sponsor disclosures and IP databases before making diligence decisions. Model: trialsignal-ai-v1.

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