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NCT02471196COMPLETEDanonymous

Efficacy of ORM-12741 on Agitation/Aggression Symptoms in Patients With Alzheimer's Disease: A Randomised, Double-blind, Placebo-controlled, Parallel Group, Multicentre Study of 12 Weeks

Sponsor

Source record

Orion Corporation, Orion Pharma

Phase

Source record

Phase 2

Modality

AI-normalized

small molecule

Target

AI-normalized

Alpha-2C adrenoceptor (AR)

Indication / condition

AI-normalized

Alzheimer's Disease

Intervention

Source record

ORM-12741, ORM-12741, Placebo

Source & freshness

Source record

NCT ID

NCT02471196

Original source

ClinicalTrials.gov

Source last updated

Feb 15, 2018

Ingested at

Jun 13, 2026

Internal sync

Jun 13, 2026

Model version

trialsignal-ai-v1

Normalized confidence

96%

Validation status

validated

Open original registry record
View original source fields

NCT ID

NCT02471196

Title

Efficacy of ORM-12741 on Agitation/Aggression Symptoms in Patients With Alzheimer's Disease: A Randomised, Double-blind, Placebo-controlled, Parallel Group, Multicentre Study of 12 Weeks

Sponsor

Orion Corporation, Orion Pharma

Status

COMPLETED

Phase

Phase 2

Condition raw

Alzheimer's Disease

Condition normalized

Alzheimer's Disease

Modality raw

small molecule

Modality normalized

small molecule

Target raw

Alpha-2C adrenoceptor (AR)

Target normalized

Alpha-2C adrenoceptor (AR)

Interventions

ORM-12741, ORM-12741, Placebo

Public preview

Source record

ORM-12741, developed by Orion Corporation in collaboration with Janssen Pharmaceuticals, targets agitation and aggression symptoms in Alzheimer's disease, a significant unmet need in the market. The Alzheimer's disease therapeutics market is projected to grow substantially, driven by increasing prevalence and demand for effective treatments. The competitive landscape includes established therapies like cholinesterase inhibitors and memantine, but there remains a gap for targeted neuropsychiatric symptom management. Successful outcomes from this trial could position ORM-12741 as a novel treatment option, potentially enhancing Orion's portfolio and market share in the neurodegenerative disease space.

AI-generated analysis supports research triage only. Verify source records, publications, sponsor disclosures and IP databases before making diligence decisions. Model: trialsignal-ai-v1.

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