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NCT01446783COMPLETEDanonymous

IGF-I Stimulation of Collagen Synthesis in Ehlers-Danlos Patients

Sponsor

Source record

Bispebjerg Hospital

Phase

Source record

Not Applicable

Modality

AI-normalized

small molecule

Target

AI-normalized

Insulin-like growth factor-I (IGF-I) signaling pathway, specifically its role in collagen synthesis.

Indication / condition

AI-normalized

Ehlers-Danlos Syndrome, Classic

Intervention

Source record

mecasermin, Saline

Source & freshness

Source record

NCT ID

NCT01446783

Original source

ClinicalTrials.gov

Source last updated

Nov 20, 2012

Ingested at

Jun 13, 2026

Internal sync

Jun 13, 2026

Model version

trialsignal-ai-v1

Normalized confidence

96%

Validation status

validated

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NCT ID

NCT01446783

Title

IGF-I Stimulation of Collagen Synthesis in Ehlers-Danlos Patients

Sponsor

Bispebjerg Hospital

Status

COMPLETED

Phase

Not Applicable

Condition raw

Ehlers-Danlos Syndrome, Classic

Condition normalized

Ehlers-Danlos Syndrome, Classic

Modality raw

small molecule

Modality normalized

small molecule

Target raw

Insulin-like growth factor-I (IGF-I) signaling pathway, specifically its role in collagen synthesis.

Target normalized

Insulin-like growth factor-I (IGF-I) signaling pathway, specifically its role in collagen synthesis.

Interventions

mecasermin, Saline

Public preview

Source record

The clinical trial conducted by Bispebjerg Hospital investigates the potential of IGF-I (mecasermin) to enhance collagen synthesis in patients with Ehlers-Danlos syndrome (EDS), a rare connective tissue disorder. Given the limited treatment options for EDS, a successful outcome could position mecasermin as a novel therapeutic approach, potentially capturing a niche market. The trial's completion in 2012 suggests that data may be available for further analysis, which could inform future development strategies. Competitive implications include the need to assess other therapies targeting collagen synthesis or connective tissue disorders, as well as the potential for partnerships or licensing opportunities based on trial outcomes.

AI-generated analysis supports research triage only. Verify source records, publications, sponsor disclosures and IP databases before making diligence decisions. Model: trialsignal-ai-v1.

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