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NCT05868382COMPLETEDanonymous

A Phase 2, Randomized, Active-Controlled, Observer-Blind, Dose-Ranging Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of mRNA Vaccine Candidate Variations in Healthy Adults 18 to 49 Years of Age

Sponsor

Source record

ModernaTX, Inc.

Phase

Source record

Phase 2

Modality

AI-normalized

RNA therapy

Target

AI-normalized

mRNA-1010 vaccine candidate variations targeting influenza A and B strains.

Indication / condition

AI-normalized

Influenza

Intervention

Source record

mRNA-1010, mRNA-1010.4, mRNA-1010.6

Source & freshness

Source record

NCT ID

NCT05868382

Original source

ClinicalTrials.gov

Source last updated

Dec 20, 2024

Ingested at

Jun 13, 2026

Internal sync

Jun 13, 2026

Model version

trialsignal-ai-v1

Normalized confidence

96%

Validation status

validated

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NCT ID

NCT05868382

Title

A Phase 2, Randomized, Active-Controlled, Observer-Blind, Dose-Ranging Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of mRNA Vaccine Candidate Variations in Healthy Adults 18 to 49 Years of Age

Sponsor

ModernaTX, Inc.

Status

COMPLETED

Phase

Phase 2

Condition raw

Influenza

Condition normalized

Influenza

Modality raw

RNA therapy

Modality normalized

RNA therapy

Target raw

mRNA-1010 vaccine candidate variations targeting influenza A and B strains.

Target normalized

mRNA-1010 vaccine candidate variations targeting influenza A and B strains.

Interventions

mRNA-1010, mRNA-1010.4, mRNA-1010.6

Public preview

Source record

ModernaTX, Inc. is advancing its mRNA-1010 vaccine candidate through a Phase 2 clinical trial aimed at evaluating safety, reactogenicity, and immunogenicity in healthy adults aged 18 to 49. The influenza vaccine market is highly competitive, with established players like Sanofi and GlaxoSmithKline. The successful development of mRNA-1010 could position Moderna favorably in the seasonal influenza vaccine market, especially given the growing acceptance of mRNA technology post-COVID-19. Diligence should focus on the trial's safety profile and immunogenicity data, which will be critical for regulatory approval and market entry.

AI-generated analysis supports research triage only. Verify source records, publications, sponsor disclosures and IP databases before making diligence decisions. Model: trialsignal-ai-v1.

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