Report workspace

Add to folder
NCT02284074COMPLETEDanonymous

Nasal Lipopolysaccharide (LPS) Challenge in Healthy Volunteers (HVs): Investigation of Tolerability, Dose Response and the Expression Profile of Intercellular Adhesion Molecule-1 (ICAM-1)

Sponsor

Source record

Imperial College London

Phase

Source record

Not Applicable

Modality

AI-normalized

RNA therapy

Target

AI-normalized

Intercellular Adhesion Molecule-1 (ICAM-1)

Indication / condition

AI-normalized

Healthy

Intervention

Source record

Nasal LPS spray, Experimental: Nasal LPS spray 1µg, Experimental: Nasal LPS spray 10 µg, Experimental: Nasal LPS spray 30 µg, Experimental: Nasal LPS spray 100 µg

Source & freshness

Source record

NCT ID

NCT02284074

Original source

ClinicalTrials.gov

Source last updated

Sep 15, 2023

Ingested at

Jun 13, 2026

Internal sync

Jun 13, 2026

Model version

trialsignal-ai-v1

Normalized confidence

96%

Validation status

validated

Open original registry record
View original source fields

NCT ID

NCT02284074

Title

Nasal Lipopolysaccharide (LPS) Challenge in Healthy Volunteers (HVs): Investigation of Tolerability, Dose Response and the Expression Profile of Intercellular Adhesion Molecule-1 (ICAM-1)

Sponsor

Imperial College London

Status

COMPLETED

Phase

Not Applicable

Condition raw

Healthy

Condition normalized

Healthy

Modality raw

RNA therapy

Modality normalized

RNA therapy

Target raw

Intercellular Adhesion Molecule-1 (ICAM-1)

Target normalized

Intercellular Adhesion Molecule-1 (ICAM-1)

Interventions

Nasal LPS spray, Experimental: Nasal LPS spray 1µg, Experimental: Nasal LPS spray 10 µg, Experimental: Nasal LPS spray 30 µg, Experimental: Nasal LPS spray 100 µg

Public preview

Source record

The nasal lipopolysaccharide (LPS) challenge study conducted by Imperial College London aims to establish a model for assessing inflammation in the nasal cavity, which could have significant implications for the development of therapeutic agents targeting respiratory diseases such as asthma, COPD, and allergic rhinitis. The collaboration with GlaxoSmithKline suggests potential interest in translating findings into drug development. The market for respiratory therapeutics is substantial, with increasing prevalence of asthma and COPD globally, indicating a favorable environment for new treatments. The study's completion may enhance understanding of inflammatory pathways, providing a competitive edge in the development of novel therapies. Companies focusing on respiratory diseases should monitor the outcomes of this study for insights into biomarker development and therapeutic targets.

AI-generated analysis supports research triage only. Verify source records, publications, sponsor disclosures and IP databases before making diligence decisions. Model: trialsignal-ai-v1.

Report access

Create an account to unlock this report

Choose the access model that matches the job: one urgent report, reusable credits for project work, or unlimited monthly access with AI and folders.

Full protocol, outcomes, eligibility, contacts and results sections
Patent/IP landscape with verified records when available
Board-ready PDF export with source provenance
Save to folders and synthesize multiple assets in premium workspace
Create account

Create a free account first, then unlock a single report, buy credits or subscribe.