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Clinical trial intelligence report
Nasal Lipopolysaccharide (LPS) Challenge in Healthy Volunteers (HVs): Investigation of Tolerability, Dose Response and the Expression Profile of Intercellular Adhesion Molecule-1 (ICAM-1)
Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.
Generated
Jun 16, 2026
NCT ID
NCT02284074
Status
COMPLETED
Phase
Not Applicable
Sponsor
Imperial College London
Executive brief
Investment-Ready Snapshot
The nasal lipopolysaccharide (LPS) challenge study conducted by Imperial College London aims to establish a model for assessing inflammation in the nasal cavity, which could have significant implications for the development of therapeutic agents targeting respiratory diseases such as asthma, COPD, and allergic rhinitis. The collaboration with GlaxoSmithKline suggests potential interest in translating findings into drug development. The market for respiratory therapeutics is substantial, with increasing prevalence of asthma and COPD globally, indicating a favorable environment for new treatments. The study's completion may enhance understanding of inflammatory pathways, providing a competitive edge in the development of novel therapies. Companies focusing on respiratory diseases should monitor the outcomes of this study for insights into biomarker development and therapeutic targets.
Source & freshness
Provenance
https://clinicaltrials.gov/study/NCT02284074
Indication
Healthy
Modality
RNA therapy
Target
Intercellular Adhesion Molecule-1 (ICAM-1)
Intervention
Nasal LPS spray, Experimental: Nasal LPS spray 1µg, Experimental: Nasal LPS spray 10 µg, Experimental: Nasal LPS spray 30 µg, Experimental: Nasal LPS spray 100 µg
Source record
Protocol Description
Detailed source ingestion pending.
Source record
Outcome Measures
Detailed source ingestion pending.
Source record
Eligibility
Detailed source ingestion pending.
AI analysis
Known Results And Readout Context
Detailed source ingestion pending.
IP intelligence
Patent And IP Landscape
Detailed source ingestion pending.
Source record
Contacts
Detailed source ingestion pending.