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NCT06321289RECRUITINGanonymous

Allogeneic TRAC Locus-inserted CD19-targeting Synthetic T-cell Receptor Antigen Receptor (STAR) T Cells for Relapsed/Refractory B-cell Non-Hodgkin's Lymphoma

Sponsor

Source record

Chinese PLA General Hospital

Phase

Source record

Phase 1/2

Modality

AI-normalized

protein therapy

Target

AI-normalized

CD19-targeting synthetic T-cell receptor (STAR) T cells utilizing CRISPR-Cas9 gene editing to knock out TRAC, HLA-A/B, CIITA, and PD-1 genes.

Indication / condition

AI-normalized

Non-hodgkin Lymphoma,B Cell

Intervention

Source record

Allogeneic CD19-STAR T cell, Fludarabine, Cyclophosphamide

Source & freshness

Source record

NCT ID

NCT06321289

Original source

ClinicalTrials.gov

Source last updated

Mar 25, 2024

Ingested at

Jun 13, 2026

Internal sync

Jun 13, 2026

Model version

trialsignal-ai-v1

Normalized confidence

96%

Validation status

validated

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NCT ID

NCT06321289

Title

Allogeneic TRAC Locus-inserted CD19-targeting Synthetic T-cell Receptor Antigen Receptor (STAR) T Cells for Relapsed/Refractory B-cell Non-Hodgkin's Lymphoma

Sponsor

Chinese PLA General Hospital

Status

RECRUITING

Phase

Phase 1/2

Condition raw

Non-hodgkin Lymphoma,B Cell

Condition normalized

Non-hodgkin Lymphoma,B Cell

Modality raw

protein therapy

Modality normalized

protein therapy

Target raw

CD19-targeting synthetic T-cell receptor (STAR) T cells utilizing CRISPR-Cas9 gene editing to knock out TRAC, HLA-A/B, CIITA, and PD-1 genes.

Target normalized

CD19-targeting synthetic T-cell receptor (STAR) T cells utilizing CRISPR-Cas9 gene editing to knock out TRAC, HLA-A/B, CIITA, and PD-1 genes.

Interventions

Allogeneic CD19-STAR T cell, Fludarabine, Cyclophosphamide

Public preview

Source record

The clinical trial, sponsored by the Chinese PLA General Hospital, is investigating an innovative allogeneic STAR T cell therapy for relapsed/refractory B-cell non-Hodgkin's lymphoma (B-NHL). The use of CRISPR-Cas9 technology to enhance T cell efficacy while minimizing graft-versus-host disease (GvHD) positions this therapy as a potentially competitive option in the CAR-T landscape. The market for B-NHL therapies is substantial, with increasing demand for effective treatments in relapsed cases. The trial's focus on multiple B-NHL subtypes broadens its potential patient population, enhancing commercial viability. However, the competitive landscape includes established CAR-T therapies and emerging TCR therapies, necessitating careful monitoring of clinical outcomes and market reception.

AI-generated analysis supports research triage only. Verify source records, publications, sponsor disclosures and IP databases before making diligence decisions. Model: trialsignal-ai-v1.

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