TrialSignal
Clinical trial intelligence report
Allogeneic TRAC Locus-inserted CD19-targeting Synthetic T-cell Receptor Antigen Receptor (STAR) T Cells for Relapsed/Refractory B-cell Non-Hodgkin's Lymphoma
Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.
Generated
Jun 16, 2026
NCT ID
NCT06321289
Status
RECRUITING
Phase
Phase 1/2
Sponsor
Chinese PLA General Hospital
Executive brief
Investment-Ready Snapshot
The clinical trial, sponsored by the Chinese PLA General Hospital, is investigating an innovative allogeneic STAR T cell therapy for relapsed/refractory B-cell non-Hodgkin's lymphoma (B-NHL). The use of CRISPR-Cas9 technology to enhance T cell efficacy while minimizing graft-versus-host disease (GvHD) positions this therapy as a potentially competitive option in the CAR-T landscape. The market for B-NHL therapies is substantial, with increasing demand for effective treatments in relapsed cases. The trial's focus on multiple B-NHL subtypes broadens its potential patient population, enhancing commercial viability. However, the competitive landscape includes established CAR-T therapies and emerging TCR therapies, necessitating careful monitoring of clinical outcomes and market reception.
Source & freshness
Provenance
https://clinicaltrials.gov/study/NCT06321289
Indication
Non-hodgkin Lymphoma,B Cell
Modality
protein therapy
Target
CD19-targeting synthetic T-cell receptor (STAR) T cells utilizing CRISPR-Cas9 gene editing to knock out TRAC, HLA-A/B, CIITA, and PD-1 genes.
Intervention
Allogeneic CD19-STAR T cell, Fludarabine, Cyclophosphamide
Source record
Protocol Description
Detailed source ingestion pending.
Source record
Outcome Measures
Detailed source ingestion pending.
Source record
Eligibility
Detailed source ingestion pending.
AI analysis
Known Results And Readout Context
Detailed source ingestion pending.
IP intelligence
Patent And IP Landscape
Detailed source ingestion pending.
Source record
Contacts
Detailed source ingestion pending.