TrialSignal
Clinical trial intelligence report
Effect of Bile Acids in the Gut on GLP-1 Secretion in Healthy Subjects and Patients With Type 2 Diabetes
Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.
Generated
Jun 16, 2026
NCT ID
NCT01666223
Status
COMPLETED
Phase
Completed (not classified in traditional phases)
Sponsor
University Hospital, Gentofte, Copenhagen
Executive brief
Investment-Ready Snapshot
This study investigates the role of bile acids in enhancing GLP-1 secretion, which has significant implications for the treatment of Type 2 Diabetes and obesity. Given the rising prevalence of these conditions, the potential therapeutic applications of bile acid modulation could position this research favorably within the diabetes treatment market. The findings may provide insights into new treatment modalities that could compete with existing GLP-1 receptor agonists and DPP-4 inhibitors. Companies focusing on metabolic diseases may consider this research for potential partnerships or acquisitions, especially if the results indicate a novel mechanism of action or improved patient outcomes.
Source & freshness
Provenance
https://clinicaltrials.gov/study/NCT01666223
Indication
Type 2 Diabetes
Modality
small molecule
Target
GLP-1 secretion modulation via bile acids, specifically through the TGR5 receptor.
Intervention
Colesevelam, Chenodeoxycholic Acid, saline, Colesevelam 3750 mg + chenodeoxycholic acid 1250 mg
Source record
Protocol Description
Detailed source ingestion pending.
Source record
Outcome Measures
Detailed source ingestion pending.
Source record
Eligibility
Detailed source ingestion pending.
AI analysis
Known Results And Readout Context
Detailed source ingestion pending.
IP intelligence
Patent And IP Landscape
Detailed source ingestion pending.
Source record
Contacts
Detailed source ingestion pending.