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NCT04588649COMPLETEDanonymous

The Aging Brain and Cognition: Contribution of Vascular Injury, Amyloid Plaque and Tau Protein to Cognitive Dysfunction After Stroke

Sponsor

Source record

Chang Gung Memorial Hospital

Phase

Source record

Phase 2

Modality

AI-normalized

small molecule

Target

AI-normalized

Vascular injury, amyloid plaque, and tau protein as contributors to cognitive dysfunction post-stroke.

Indication / condition

AI-normalized

Post-stroke Dementia

Intervention

Source record

THK-5351, AV-45

Source & freshness

Source record

NCT ID

NCT04588649

Original source

ClinicalTrials.gov

Source last updated

May 06, 2023

Ingested at

Jun 12, 2026

Internal sync

Jun 12, 2026

Model version

trialsignal-ai-v1

Normalized confidence

96%

Validation status

validated

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View original source fields

NCT ID

NCT04588649

Title

The Aging Brain and Cognition: Contribution of Vascular Injury, Amyloid Plaque and Tau Protein to Cognitive Dysfunction After Stroke

Sponsor

Chang Gung Memorial Hospital

Status

COMPLETED

Phase

Phase 2

Condition raw

Post-stroke Dementia, Vascular Mild Cognitive Impairment

Condition normalized

Post-stroke Dementia, Vascular Mild Cognitive Impairment

Modality raw

small molecule

Modality normalized

small molecule

Target raw

Vascular injury, amyloid plaque, and tau protein as contributors to cognitive dysfunction post-stroke.

Target normalized

Vascular injury, amyloid plaque, and tau protein as contributors to cognitive dysfunction post-stroke.

Interventions

THK-5351, AV-45

Public preview

Source record

The study, sponsored by Chang Gung Memorial Hospital, investigates the interplay between vascular injury, amyloid plaques, and tau proteins in cognitive dysfunction following stroke. With approximately one-third of stroke patients developing post-stroke dementia, this research addresses a significant unmet medical need in the aging population. The findings could inform the development of diagnostic tools or therapeutic strategies targeting cognitive impairment in stroke patients, potentially positioning the sponsor as a leader in this niche market. The competitive landscape includes other neuroimaging studies and dementia-related therapeutics, necessitating a thorough diligence assessment to identify potential collaborators or competitors in the field.

AI-generated analysis supports research triage only. Verify source records, publications, sponsor disclosures and IP databases before making diligence decisions. Model: trialsignal-ai-v1.

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