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NCT05631912UNKNOWNanonymous

Autologous TRAC Locus-inserted CD19-targeting Synthetic T-cell Receptor Antigen Receptor T (STAR-T) Cells for Relapsed/Refractory B-cell Non-Hodgkin's Lymphoma

Sponsor

Source record

Chinese PLA General Hospital

Phase

Source record

Phase 1/2

Modality

AI-normalized

protein therapy

Target

AI-normalized

CD19-targeting synthetic T-cell receptor (STAR) utilizing CRISPR/Cas9 technology to disrupt the TRAC locus for enhanced T-cell therapy.

Indication / condition

AI-normalized

Non-hodgkin Lymphoma,B Cell

Intervention

Source record

Autologous CD19-STAR-T cell, Fludarabine, Cyclophosphamide

Source & freshness

Source record

NCT ID

NCT05631912

Original source

ClinicalTrials.gov

Source last updated

Jul 06, 2023

Ingested at

Jun 12, 2026

Internal sync

Jun 12, 2026

Model version

trialsignal-ai-v1

Normalized confidence

96%

Validation status

validated

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NCT ID

NCT05631912

Title

Autologous TRAC Locus-inserted CD19-targeting Synthetic T-cell Receptor Antigen Receptor T (STAR-T) Cells for Relapsed/Refractory B-cell Non-Hodgkin's Lymphoma

Sponsor

Chinese PLA General Hospital

Status

UNKNOWN

Phase

Phase 1/2

Condition raw

Non-hodgkin Lymphoma,B Cell

Condition normalized

Non-hodgkin Lymphoma,B Cell

Modality raw

protein therapy

Modality normalized

protein therapy

Target raw

CD19-targeting synthetic T-cell receptor (STAR) utilizing CRISPR/Cas9 technology to disrupt the TRAC locus for enhanced T-cell therapy.

Target normalized

CD19-targeting synthetic T-cell receptor (STAR) utilizing CRISPR/Cas9 technology to disrupt the TRAC locus for enhanced T-cell therapy.

Interventions

Autologous CD19-STAR-T cell, Fludarabine, Cyclophosphamide

Public preview

Source record

The clinical trial is sponsored by the Chinese PLA General Hospital and aims to evaluate the safety and efficacy of autologous CD19-targeting STAR-T cell therapy in patients with relapsed or refractory B-cell non-Hodgkin's lymphoma (B-NHL). Given the increasing prevalence of B-NHL and the limitations of existing CAR-T therapies, this innovative approach may provide a competitive edge in the CAR-T market. The trial's focus on a novel mechanism that potentially reduces toxicity while maintaining efficacy could attract interest from investors and pharmaceutical companies looking to expand their oncology portfolios. The estimated patient enrollment of 19 to 38 suggests a targeted approach that may facilitate rapid data collection and analysis, enhancing the asset's attractiveness for future partnerships or acquisitions.

AI-generated analysis supports research triage only. Verify source records, publications, sponsor disclosures and IP databases before making diligence decisions. Model: trialsignal-ai-v1.

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