TrialSignal
Clinical trial intelligence report
Autologous TRAC Locus-inserted CD19-targeting Synthetic T-cell Receptor Antigen Receptor T (STAR-T) Cells for Relapsed/Refractory B-cell Non-Hodgkin's Lymphoma
Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.
Generated
Jun 13, 2026
NCT ID
NCT05631912
Status
UNKNOWN
Phase
Phase 1/2
Sponsor
Chinese PLA General Hospital
Executive brief
Investment-Ready Snapshot
The clinical trial is sponsored by the Chinese PLA General Hospital and aims to evaluate the safety and efficacy of autologous CD19-targeting STAR-T cell therapy in patients with relapsed or refractory B-cell non-Hodgkin's lymphoma (B-NHL). Given the increasing prevalence of B-NHL and the limitations of existing CAR-T therapies, this innovative approach may provide a competitive edge in the CAR-T market. The trial's focus on a novel mechanism that potentially reduces toxicity while maintaining efficacy could attract interest from investors and pharmaceutical companies looking to expand their oncology portfolios. The estimated patient enrollment of 19 to 38 suggests a targeted approach that may facilitate rapid data collection and analysis, enhancing the asset's attractiveness for future partnerships or acquisitions.
Source & freshness
Provenance
https://clinicaltrials.gov/study/NCT05631912
Indication
Non-hodgkin Lymphoma,B Cell
Modality
protein therapy
Target
CD19-targeting synthetic T-cell receptor (STAR) utilizing CRISPR/Cas9 technology to disrupt the TRAC locus for enhanced T-cell therapy.
Intervention
Autologous CD19-STAR-T cell, Fludarabine, Cyclophosphamide
Source record
Protocol Description
Detailed source ingestion pending.
Source record
Outcome Measures
Detailed source ingestion pending.
Source record
Eligibility
Detailed source ingestion pending.
AI analysis
Known Results And Readout Context
Detailed source ingestion pending.
IP intelligence
Patent And IP Landscape
Detailed source ingestion pending.
Source record
Contacts
Detailed source ingestion pending.