Report workspace tools

NCT06838832RECRUITINGanonymous

Novel Allogenic CD19-targeting Chimeric Antigen Receptor γδT Cells Therapy (QH103E) in Patients With Relapsed or Refractory B-cell Non-Hodgkin's Lymphoma

Sponsor

Source record

Chinese PLA General Hospital

Phase

Source record

Phase 1/2

Modality

AI-normalized

protein therapy

Target

AI-normalized

CD19-targeting Chimeric Antigen Receptor (CAR) on allogeneic γδT cells

Indication / condition

AI-normalized

Non-hodgkin Lymphoma,B Cell

Intervention

Source record

Allogenic CD19-CAR-γδT cell, Fludarabine, Cyclophosphamide

Source & freshness

Source record

NCT ID

NCT06838832

Original source

ClinicalTrials.gov

Source last updated

Jul 30, 2025

Ingested at

Jun 12, 2026

Internal sync

Jun 12, 2026

Model version

trialsignal-ai-v1

Normalized confidence

96%

Validation status

validated

Open original registry record
View original source fields

NCT ID

NCT06838832

Title

Novel Allogenic CD19-targeting Chimeric Antigen Receptor γδT Cells Therapy (QH103E) in Patients With Relapsed or Refractory B-cell Non-Hodgkin's Lymphoma

Sponsor

Chinese PLA General Hospital

Status

RECRUITING

Phase

Phase 1/2

Condition raw

Non-hodgkin Lymphoma,B Cell

Condition normalized

Non-hodgkin Lymphoma,B Cell

Modality raw

protein therapy

Modality normalized

protein therapy

Target raw

CD19-targeting Chimeric Antigen Receptor (CAR) on allogeneic γδT cells

Target normalized

CD19-targeting Chimeric Antigen Receptor (CAR) on allogeneic γδT cells

Interventions

Allogenic CD19-CAR-γδT cell, Fludarabine, Cyclophosphamide

Public preview

Source record

The QH103E therapy represents a novel approach in the treatment of relapsed or refractory B-cell non-Hodgkin's lymphoma (NHL) by utilizing allogeneic γδT cells engineered to express a CD19-targeting CAR. The market for CAR T-cell therapies is rapidly expanding, with significant demand for innovative treatments in hematological malignancies. Given the increasing prevalence of NHL and the limitations of existing therapies, QH103E could capture a substantial share of this market if proven effective and safe. Competitive analysis indicates that while there are established players in the CAR T-cell space, the unique mechanism of action and potential for enhanced memory efficacy may provide a differentiated position. Diligence should focus on the regulatory pathway, potential partnerships, and reimbursement strategies, particularly in the context of the Chinese healthcare system.

AI-generated analysis supports research triage only. Verify source records, publications, sponsor disclosures and IP databases before making diligence decisions. Model: trialsignal-ai-v1.

Report access

Create an account to unlock this report

Choose the access model that matches the job: one urgent report, reusable credits for project work, or unlimited monthly access with AI and folders.

Full protocol, outcomes, eligibility, contacts and results sections
Patent/IP landscape with verified records when available
Board-ready PDF export with source provenance
Save to folders and synthesize multiple assets in premium workspace
Create account

Create a free account first, then unlock a single report, buy credits or subscribe.