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NCT05134987COMPLETEDanonymous

A Multiple Dose Study Investigating Pharmacokinetics and Pharmacodynamics of Subcutaneous NNC0363-0845 in Participants With Type 1 Diabetes

Sponsor

Source record

Novo Nordisk A/S

Phase

Source record

Phase 1

Modality

AI-normalized

small molecule

Target

AI-normalized

Insulin receptor (IR) signaling pathway, specifically targeting blood sugar-dependent insulin action.

Indication / condition

AI-normalized

Diabetes Mellitus, Type 1

Intervention

Source record

NNC0363-0845, Insulin detemir

Source & freshness

Source record

NCT ID

NCT05134987

Original source

ClinicalTrials.gov

Source last updated

Nov 04, 2022

Ingested at

Jun 11, 2026

Internal sync

Jun 11, 2026

Model version

trialsignal-ai-v1

Normalized confidence

96%

Validation status

validated

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NCT ID

NCT05134987

Title

A Multiple Dose Study Investigating Pharmacokinetics and Pharmacodynamics of Subcutaneous NNC0363-0845 in Participants With Type 1 Diabetes

Sponsor

Novo Nordisk A/S

Status

COMPLETED

Phase

Phase 1

Condition raw

Diabetes Mellitus, Type 1

Condition normalized

Diabetes Mellitus, Type 1

Modality raw

small molecule

Modality normalized

small molecule

Target raw

Insulin receptor (IR) signaling pathway, specifically targeting blood sugar-dependent insulin action.

Target normalized

Insulin receptor (IR) signaling pathway, specifically targeting blood sugar-dependent insulin action.

Interventions

NNC0363-0845, Insulin detemir

Public preview

Source record

NNC0363-0845 represents a novel insulin formulation aimed at improving glycemic control in patients with type 1 diabetes. The dual administration with insulin detemir allows for comparative analysis of pharmacokinetics and pharmacodynamics, potentially positioning NNC0363-0845 as a competitive alternative in the insulin market. Given the increasing prevalence of diabetes globally, successful outcomes could enhance Novo Nordisk's portfolio and market share in the diabetes care sector. The study's completion suggests readiness for further development stages, with implications for investor confidence and potential partnerships in diabetes management.

AI-generated analysis supports research triage only. Verify source records, publications, sponsor disclosures and IP databases before making diligence decisions. Model: trialsignal-ai-v1.

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