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NCT00187018COMPLETEDanonymous

Marrow Mesenchymal Cell Therapy for Osteogenesis Imperfecta: A Pilot Study

Sponsor

Source record

St. Jude Children's Research Hospital

Phase

Source record

NA

Modality

AI-normalized

protein therapy

Target

AI-normalized

Bone marrow transplant

Indication / condition

AI-normalized

Osteogenesis Imperfecta

Intervention

Source record

Bone marrow transplant

Source & freshness

Source record

NCT ID

NCT00187018

Original source

ClinicalTrials.gov

Source last updated

Mar 04, 2015

Ingested at

Jun 11, 2026

Internal sync

Jun 11, 2026

Model version

trialsignal-ai-v1

Normalized confidence

96%

Validation status

validated

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View original source fields

NCT ID

NCT00187018

Title

Marrow Mesenchymal Cell Therapy for Osteogenesis Imperfecta: A Pilot Study

Sponsor

St. Jude Children's Research Hospital

Status

COMPLETED

Phase

NA

Condition raw

Osteogenesis Imperfecta

Condition normalized

Osteogenesis Imperfecta

Modality raw

protein therapy

Modality normalized

protein therapy

Target raw

Bone marrow transplant

Target normalized

Bone marrow transplant

Interventions

Bone marrow transplant

Public preview

Source record

Osteogenesis imperfecta (OI) is a genetic disease for which there is currently no known cure. OI causes the osteoblasts (bone-forming cells in the body) to grow poorly, which slows the growth of children with the disease and causes their bones to bend and break easily. Some forms of osteogenesis imperfecta may cause severe disability and even death. In previous research studies performed at St. Jude, it was found that children treated with bone marrow transplant (infusion of healthy immature blood-forming cells) began to grow faster, had more minerals (material that helps make the bones strong) in their bones, and broke their bones less often than before the bone marrow transplant. Several months after the bone marrow transplant however, body growth once again began to slow down. In this research study, children with osteogenesis imperfecta will receive another infusion of bone marrow cells but without any chemotherapy. The marrow cells will come from the same bone marrow donor as their previous bone marrow transplant. It is hoped that by removing the CD3+ cells (a type of white blood cells that attack other cells that are not like themselves) from the donated bone marrow, the subject's body will be infused quite safely and that body growth and bone strength will increase. The CD3+ cells will be removed from the donor bone marrow by use of a machine called the CliniMACS System. This machine has not been approved for use in the United States by the Food and Drug Administration (FDA). The use of this device is considered experimental.

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