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NCT06895018ENROLLING_BY_INVITATIONanonymous

Medium-term Effects of a Polyphenol-rich Beverage Based on Red Grape Pomace Extract on Non-alcoholic Fatty Liver Disease, Cardiometabolic Risk Profile and Gut Microbiota in Subjects with Type 2 Diabetes

Sponsor

Source record

Federico II University

Phase

Source record

Not Applicable

Modality

AI-normalized

RNA therapy

Target

AI-normalized

Polyphenol metabolites and their phase II derivatives impacting hepatic steatosis, cardiometabolic risk, and gut microbiota composition.

Indication / condition

AI-normalized

Diabetes Mellitus Type 2

Intervention

Source record

Supplementation with Polyphenol Rich Drink, Supplementation with Control Drink (Placebo)

Source & freshness

Source record

NCT ID

NCT06895018

Original source

ClinicalTrials.gov

Source last updated

Mar 26, 2025

Ingested at

Jun 09, 2026

Internal sync

Jun 09, 2026

Model version

trialsignal-ai-v1

Normalized confidence

96%

Validation status

validated

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NCT ID

NCT06895018

Title

Medium-term Effects of a Polyphenol-rich Beverage Based on Red Grape Pomace Extract on Non-alcoholic Fatty Liver Disease, Cardiometabolic Risk Profile and Gut Microbiota in Subjects with Type 2 Diabetes

Sponsor

Federico II University

Status

ENROLLING_BY_INVITATION

Phase

Not Applicable

Condition raw

Diabetes Mellitus Type 2

Condition normalized

Diabetes Mellitus Type 2

Modality raw

RNA therapy

Modality normalized

RNA therapy

Target raw

Polyphenol metabolites and their phase II derivatives impacting hepatic steatosis, cardiometabolic risk, and gut microbiota composition.

Target normalized

Polyphenol metabolites and their phase II derivatives impacting hepatic steatosis, cardiometabolic risk, and gut microbiota composition.

Interventions

Supplementation with Polyphenol Rich Drink, Supplementation with Control Drink (Placebo)

Public preview

Source record

The study, sponsored by Federico II University, investigates the effects of a polyphenol-rich beverage derived from red grape pomace on non-alcoholic fatty liver disease (NAFLD) and related metabolic conditions in patients with type 2 diabetes. Given the rising prevalence of NAFLD and the absence of pharmacological treatments, this asset addresses a significant unmet medical need. The potential for dietary polyphenols to improve liver health and metabolic profiles could position this beverage favorably in the dietary supplement market, particularly among diabetic and obese populations. The competitive landscape includes other dietary interventions and emerging pharmacotherapies for NAFLD, necessitating a thorough market analysis and strategic positioning. Diligence should focus on regulatory pathways, especially concerning health claims and market entry strategies.

AI-generated analysis supports research triage only. Verify source records, publications, sponsor disclosures and IP databases before making diligence decisions. Model: trialsignal-ai-v1.

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