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NCT05355311COMPLETEDanonymous

L-carnitine Supplementation for Co-occurring Depression and Alcohol Use Disorder in Youth: An Open Trial Pilot Study

Sponsor

Source record

Brown University

Phase

Source record

PHASE1

Modality

AI-normalized

small molecule

Target

AI-normalized

L-carnitine

Indication / condition

AI-normalized

Alcohol Use Disorder

Intervention

Source record

L-carnitine

Source & freshness

Source record

NCT ID

NCT05355311

Original source

ClinicalTrials.gov

Source last updated

Jun 15, 2025

Ingested at

Jun 08, 2026

Internal sync

Jun 08, 2026

Model version

trialsignal-ai-v1

Normalized confidence

96%

Validation status

validated

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View original source fields

NCT ID

NCT05355311

Title

L-carnitine Supplementation for Co-occurring Depression and Alcohol Use Disorder in Youth: An Open Trial Pilot Study

Sponsor

Brown University

Status

COMPLETED

Phase

PHASE1

Condition raw

Alcohol Use Disorder

Condition normalized

Alcohol Use Disorder

Modality raw

small molecule

Modality normalized

small molecule

Target raw

L-carnitine

Target normalized

L-carnitine

Interventions

L-carnitine

Public preview

Source record

The primary objective of this study is to evaluate the effects of L-carnitine, 2.97g daily on alcohol cue-elicited alcohol craving during a human laboratory paradigm after 4 weeks of daily dosing among participants ages 18-25 with alcohol use disorder (AUD) as confirmed by the Diagnostic and Statistical Manual of Mental Disorders - Fifth Edition (DSM-5™) and who report at least mild depressive symptoms on the Beck Depression Inventory-II. Secondary objectives include evaluation of L-carnitine (2.97g/day) on alcohol craving and use, subjective effects of alcohol consumption, mood, sleep, alcohol use negative consequences, study retention, and safety and tolerability.

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