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NCT05471687UNKNOWNanonymous

Evaluation of the Functional Impact of Coronary Stenoses in Diabetics by Spectral CT

Sponsor

Source record

Hospices Civils de Lyon

Phase

Source record

NA

Modality

AI-normalized

medical device

Target

AI-normalized

dual-energy dual-layer spectral scanner, Stress protocol with adenosin during dual-energy dual-layer spectral scanner

Indication / condition

AI-normalized

Coronary Stenosis

Intervention

Source record

dual-energy dual-layer spectral scanner, Stress protocol with adenosin during dual-energy dual-layer spectral scanner

Source & freshness

Source record

NCT ID

NCT05471687

Original source

ClinicalTrials.gov

Source last updated

Jul 25, 2022

Ingested at

Jun 08, 2026

Internal sync

Jun 08, 2026

Model version

trialsignal-ai-v1

Normalized confidence

96%

Validation status

validated

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NCT ID

NCT05471687

Title

Evaluation of the Functional Impact of Coronary Stenoses in Diabetics by Spectral CT

Sponsor

Hospices Civils de Lyon

Status

UNKNOWN

Phase

NA

Condition raw

Coronary Stenosis, Diabetic

Condition normalized

Coronary Stenosis, Diabetic

Modality raw

medical device

Modality normalized

medical device

Target raw

dual-energy dual-layer spectral scanner, Stress protocol with adenosin during dual-energy dual-layer spectral scanner

Target normalized

dual-energy dual-layer spectral scanner, Stress protocol with adenosin during dual-energy dual-layer spectral scanner

Interventions

dual-energy dual-layer spectral scanner, Stress protocol with adenosin during dual-energy dual-layer spectral scanner

Public preview

Source record

The optimal screening methods for coronary insufficiency, a frequent and pejorative complication in diabetics, are subject to debate, particularly in situations of silent myocardial ischemia. The contemporary strategy consists of pre-selecting asymptomatic patients at very high cardiovascular (CV) risk by performing a coronary calcium score. If this is found to be high \>300 AU (Agatston units), the patient is suspected of being at high risk of silent myocardial ischemia (SMI), and the assessment is completed to exclude the presence of coronary artery disease likely to benefit from revascularization.

The complementary evaluation consists in evaluating the myocardial perfusion to judge the perfusion repercussions. The most common examination to date is myocardial scintigraphy, because stress tests are too frequently submaximal in diabetics. However, the reproducibility of scintigraphy is controversial and their sensitivity and specificity are debated in this indication.

This problem is similar in stable symptomatic coronary diabetic patients for whom an indication for functional examinations is justified.

The double-energy double-layer spectral scanner (SDEDC) could now become a relevant tool in this field, since it can combine not only anatomical data (identification of coronary stenosis) but also functional data (myocardial perfusion) during a stress protocol. thanks to the spectral images which make it possible to measure the tissue concentration of intramyocardial iodine downstream of the considered stenosis.

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