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Evaluation of the Functional Impact of Coronary Stenoses in Diabetics by Spectral CT
Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.
Generated
Jun 13, 2026
NCT ID
NCT05471687
Status
UNKNOWN
Phase
NA
Sponsor
Hospices Civils de Lyon
Executive brief
Investment-Ready Snapshot
The optimal screening methods for coronary insufficiency, a frequent and pejorative complication in diabetics, are subject to debate, particularly in situations of silent myocardial ischemia. The contemporary strategy consists of pre-selecting asymptomatic patients at very high cardiovascular (CV) risk by performing a coronary calcium score. If this is found to be high \>300 AU (Agatston units), the patient is suspected of being at high risk of silent myocardial ischemia (SMI), and the assessment is completed to exclude the presence of coronary artery disease likely to benefit from revascularization. The complementary evaluation consists in evaluating the myocardial perfusion to judge the perfusion repercussions. The most common examination to date is myocardial scintigraphy, because stress tests are too frequently submaximal in diabetics. However, the reproducibility of scintigraphy is controversial and their sensitivity and specificity are debated in this indication. This problem is similar in stable symptomatic coronary diabetic patients for whom an indication for functional examinations is justified. The double-energy double-layer spectral scanner (SDEDC) could now become a relevant tool in this field, since it can combine not only anatomical data (identification of coronary stenosis) but also functional data (myocardial perfusion) during a stress protocol. thanks to the spectral images which make it possible to measure the tissue concentration of intramyocardial iodine downstream of the considered stenosis.
Source & freshness
Provenance
https://clinicaltrials.gov/study/NCT05471687
Indication
Coronary Stenosis
Modality
medical device
Target
dual-energy dual-layer spectral scanner, Stress protocol with adenosin during dual-energy dual-layer spectral scanner
Intervention
dual-energy dual-layer spectral scanner, Stress protocol with adenosin during dual-energy dual-layer spectral scanner
Source record
Protocol Description
Detailed source ingestion pending.
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Outcome Measures
Detailed source ingestion pending.
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Eligibility
Detailed source ingestion pending.
AI analysis
Known Results And Readout Context
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IP intelligence
Patent And IP Landscape
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Contacts
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