Report workspace tools

NCT03960554TERMINATEDanonymous

The Effects of 12-months of Denosumab on Bone Density, Quality and Strength in Prevalent Kidney Transplant Recipients

Sponsor

Source record

Thomas Nickolas, MD MS

Phase

Source record

PHASE2

Modality

AI-normalized

monoclonal antibody

Target

AI-normalized

Denosumab Inj 60 mg/ml, Placebo

Indication / condition

AI-normalized

Osteoporosis

Intervention

Source record

Denosumab Inj 60 mg/ml, Placebo

Source & freshness

Source record

NCT ID

NCT03960554

Original source

ClinicalTrials.gov

Source last updated

Jul 25, 2024

Ingested at

May 21, 2026

Internal sync

May 23, 2026

Model version

trialsignal-ai-v1

Normalized confidence

96%

Validation status

validated

Open original registry record
View original source fields

NCT ID

NCT03960554

Title

The Effects of 12-months of Denosumab on Bone Density, Quality and Strength in Prevalent Kidney Transplant Recipients

Sponsor

Thomas Nickolas, MD MS

Status

TERMINATED

Phase

PHASE2

Condition raw

Osteoporosis, Renal Osteodystrophy, Kidney Transplant; Complications

Condition normalized

Osteoporosis, Renal Osteodystrophy, Kidney Transplant; Complications

Modality raw

monoclonal antibody

Modality normalized

monoclonal antibody

Target raw

Denosumab Inj 60 mg/ml, Placebo

Target normalized

Denosumab Inj 60 mg/ml, Placebo

Interventions

Denosumab Inj 60 mg/ml, Placebo

Public preview

Source record

This is a Phase 2 Multi-Center Clinical Trial (safety and effectiveness trial) in 60 patients (40 denosumab; 20 placebo) who have had a kidney transplant for 12-months or longer with more than 30% of kidney function. The investigators will test whether denosumab safely improves bone mineral density (BMD) by dual-energy X-ray absorptiometry (DXA) and improves bone strength by high resolution peripheral quantitative computed tomography (HR-pQCT) in the subset of patients recruited at Columbia University Irving Medical Center. These data will inform the development and execution of a larger trial to test if denosumab prevents fractures in kidney transplant recipients.

AI-generated analysis supports research triage only. Verify source records, publications, sponsor disclosures and IP databases before making diligence decisions. Model: trialsignal-ai-v1.

Report access

Create an account to unlock this report

Choose the access model that matches the job: one urgent report, reusable credits for project work, or unlimited monthly access with AI and folders.

Full protocol, outcomes, eligibility, contacts and results sections
Patent/IP landscape with verified records when available
Board-ready PDF export with source provenance
Save to folders and synthesize multiple assets in premium workspace
Create account

Create a free account first, then unlock a single report, buy credits or subscribe.