A Safety and Efficacy Study of Transcription Activator-like Effector Nucleases and Clustered Regularly Interspaced Short Palindromic Repeat/Cas9 in the Treatment of HPV-related Cervical Intraepithelial NeoplasiaⅠ
This clinical trial, sponsored by the First Affiliated Hospital of Sun Yat-Sen University, aims to evaluate the safety and efficacy of TALEN and CRISPR/Cas9 gene editing technologies in treating HPV-related cervical intraepithelial neoplasia (CIN). Given the prevalence of HPV infections and the associated risk of cervical cancer, successful outcomes could position these gene-editing therapies as innovative treatment options in a market with significant unmet needs. The competitive landscape includes traditional HPV treatments and emerging gene therapies, necessitating thorough diligence on regulatory pathways and potential market entry strategies.
Indication: Human Papillomavirus-Related Malignant Neoplasm
Modality: protein therapy
Target: Transcription Activator-like Effector Nucleases (TALEN) and Clustered Regularly Interspaced Short Palindromic Repeat/Cas9 (CRISPR/Cas9) targeting HPV16 and HPV18 E6/E7 genes.
Sponsor: First Affiliated Hospital, Sun Yat-Sen University
Source URL: ClinicalTrials.gov
Source updated: Detailed source ingestion pending
Ingested: Jul 14, 2026
Model: trialsignal-ai-v1
Validation: validated
Matched by target_normalized: Transcription Activator-like Effector Nucleases (TALEN) and Clustered Regularly Interspaced Short Palindromic Repeat/Cas9 (CRISPR/Cas9) targeting HPV16 and HPV18 E6/E7 genes.
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Condition raw: Human Papillomavirus-Related Malignant Neoplasm
Condition normalized: Human Papillomavirus-Related Malignant Neoplasm
Modality raw: protein therapy
Modality normalized: protein therapy
Target raw: Transcription Activator-like Effector Nucleases (TALEN) and Clustered Regularly Interspaced Short Palindromic Repeat/Cas9 (CRISPR/Cas9) targeting HPV16 and HPV18 E6/E7 genes.
Target normalized: Transcription Activator-like Effector Nucleases (TALEN) and Clustered Regularly Interspaced Short Palindromic Repeat/Cas9 (CRISPR/Cas9) targeting HPV16 and HPV18 E6/E7 genes.